Preliminary analysis of the antinociceptive activity of zerumbone

被引：48

作者：

Sulaiman, M. R. ^{[1
]}

Perimal, E. K. ^{[1
]}

Zakaria, Z. A. ^{[2
]}

Mokhtar, F. ^{[3
]}

Akhtar, M. N. ^{[3
]}

Lajis, N. H. ^{[3
]}

Israf, D. A. ^{[1
]}

机构：

[1] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Selangor, Malaysia

[2] Univ Teknologi Mara, Fac Pharm, Dept Pharmaceut Sci, Shah Alam 40450, Selangor, Malaysia

[3] Univ Putra Malaysia, Inst Biosci, Serdang 43400, Selangor, Malaysia

来源：

FITOTERAPIA | 2009年 / 80卷 / 04期

关键词：

Zerumbone; Antinociceptive; Acetic acid-induced abdominal constriction test; Hot plate test; FREE-RADICAL GENERATION; ZINGIBER-ZERUMBET; GINGER SESQUITERPENE; FORMALIN TEST; CHEMOPREVENTION; CONSTITUENTS; SUPPRESSION; EXTRACTS; DRUGS; MICE;

D O I：

10.1016/j.fitote.2009.02.002

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have investigated the antinociceptive activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith, in acetic acid-induced abdominal writhing test and hot plate test in mice. 1 given by intraperitoneal route produced significant dose-dependent antinociceptive effect in all the test models used. In addition, the antinociceptive effect of I in the hot plate test was reversed by the non-selective opioid receptor antagonist naloxone, suggesting that the opioid system is involved in its analgesic mechanism of action. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：230 / 232

页数：3

共 23 条

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