ANALYSIS OF CARBOHYDRATES AND GLYCOCONJUGATES BY MATRIX-ASSISTED LASER DESORPTION/IONIZATION MASS SPECTROMETRY: AN UPDATE FOR 2013-2014

被引：47

作者：

Harvey, David J. ^{[1
]}

机构：

[1] Univ Oxford, Target Discovery Inst, Nuffield Dept Med, Roosevelt Dr, Oxford OX3 7FZ, England

来源：

MASS SPECTROMETRY REVIEWS | 2018年 / 37卷 / 04期

关键词：

carbohydrates; matrix-assisted laser desorption/ionization (MALDI); glycoproteins; glycolipids; matrices; biopharmaceuticals natural products; MALDI-TOF-MS; PENTASACCHARIDE REPEATING UNIT; N-LINKED GLYCOPEPTIDES; HIGHLY SPECIFIC ENRICHMENT; PLANT-CELL WALL; PORPHYROMONAS-GINGIVALIS LIPOPOLYSACCHARIDE; MILK OLIGOSACCHARIDE STRUCTURES; BORONATE AFFINITY MONOLITH; DESORPTION IONIZATION-TIME; THIN-LAYER-CHROMATOGRAPHY;

D O I：

10.1002/mas.21530

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

This review is the eighth update of the original article published in 1999 on the application of Matrix-assisted laser desorption/ionization mass spectrometry (MALDI) mass spectrometry to the analysis of carbohydrates and glycoconjugates and brings coverage of the literature to the end of 2014. Topics covered in the first part of the review include general aspects such as theory of the MALDI process, matrices, derivatization, MALDI imaging, fragmentation, and arrays. The second part of the review is devoted to applications to various structural types such as oligo- and poly- saccharides, glycoproteins, glycolipids, glycosides, and biopharmaceuticals. Much of this material is presented in tabular form. The third part of the review covers medical and industrial applications of the technique, studies of enzyme reactions, and applications to chemical synthesis. (C) 2018 Wiley Periodicals, Inc.

引用

页码：353 / 491

页数：139

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