SYNTHETIC STUDIES TOWARD (+)-LYSERGIC ACID: CONSTRUCTION OF THE TETRACYCLIC ERGOLINE SKELETON

被引：31

作者：

Inoue, Tohru ^{[1
]}

Yokoshima, Satoshi ^{[1
]}

Fukuyama, Tohru ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

HETEROCYCLES | 2009年 / 79卷

关键词：

Alkaloid; Indole; Electrocyclic Reaction; Heck Reaction; Carbonylation; (+/-)-LYSERGIC ACID; ERGOT ALKALOIDS; LYSERGIC-ACID; (&/-)-LYSERGIC ACID; ROUTE;

D O I：

10.3987/COM-08-S(D)42

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have successfully constructed the tetracyclic skeleton of lysergic acid, which features an acylation at the C3 position of the indole as well as an intramolecular Heck reaction. The optically active D ring unit could be derived from L-pyroglutamic acid via a disrotatory electrocyclic reaction of a dibromocyclopropane.

引用

页码：373 / 378

页数：6

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