Optimization of propagation-based x-ray phase-contrast tomography for breast cancer imaging

被引:49
作者
Baran, P. [1 ]
Pacile, S. [2 ,3 ]
Nesterets, Y. I. [4 ,5 ]
Mayo, S. C. [4 ]
Dullin, C. [6 ]
Dreossi, D. [2 ]
Arfelli, F. [2 ,7 ,8 ]
Thompson, D. [4 ,5 ]
Lockie, D. [9 ]
McCormack, M. [10 ]
Taba, S. T. [11 ]
Brun, F. [2 ,3 ]
Pinamonti, M. [12 ]
Nickson, C. [13 ]
Hall, C. [14 ]
Dimmock, M. [15 ]
Zanconati, F. [12 ]
Cholewa, M. [16 ]
Quiney, H. [1 ]
Brennan, P. C. [11 ]
Tromba, G. [2 ]
Gureyev, T. E. [1 ,4 ,5 ,17 ]
机构
[1] Univ Melbourne, ARC Ctr Excellence Adv Mol Imaging, Sch Phys, Parkville, Vic 3010, Australia
[2] Elettra Sincrotrone, I-34149 Trieste, Italy
[3] Univ Trieste, Dept Engn & Architecture, I-34127 Trieste, Italy
[4] Commonwealth Sci & Ind Res Org, Clayton, Vic 3168, Australia
[5] Univ New England, Sch Sci & Technol, Armidale, NSW 2351, Australia
[6] Univ Hosp Gottingen, Dept Diagnost & Intervent Radiol, D-37075 Gottingen, Germany
[7] Univ Trieste, Dept Phys, I-34127 Trieste, Italy
[8] Ist Nazl Fis Nucl, I-34127 Trieste, Italy
[9] Maroondah BreastScreen, Ringwood 3135, Australia
[10] TissuPath Specialist Pathol Serv, Mt Waverley, Vic 3149, Australia
[11] Univ Sydney, Fac Hlth Sci, Lidcombe 2141, Australia
[12] Acad Hosp Trieste, Dept Pathol, I-34128 Trieste, Italy
[13] Univ Melbourne, Melbourne Sch Populat & Global Hlth, Carlton, Vic 3053, Australia
[14] Australian Synchrotron, Clayton, Vic 3168, Australia
[15] Monash Univ, Dept Med Imaging & Radiat Sci, Clayton, Vic 3800, Australia
[16] Univ Rzeszow, Fac Math & Nat Sci, Dept Biophys, PL-35310 Rzeszow, Poland
[17] Monash Univ, Sch Phys & Astron, Clayton, Vic 3800, Australia
关键词
x-ray imaging; mammography; breast cancer; computed tomography; x-ray phase contrast; SYNCHROTRON-RADIATION; COMPUTED-TOMOGRAPHY; DIGITAL MAMMOGRAPHY; TOMOSYNTHESIS; RESOLUTION; ENERGY;
D O I
10.1088/1361-6560/aa5d3d
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
The aim of this study was to optimise the experimental protocol and data analysis for in-vivo breast cancer x-ray imaging. Results are presented of the experiment at the SYRMEP beamline of Elettra Synchrotron using the propagation-based phase-contrast mammographic tomography method, which incorporates not only absorption, but also x-ray phase information. In this study the images of breast tissue samples, of a size corresponding to a full human breast, with radiologically acceptable x-ray doses were obtained, and the degree of improvement of the image quality (from the diagnostic point of view) achievable using propagation-based phase-contrast image acquisition protocols with proper incorporation of x-ray phase retrieval into the reconstruction pipeline was investigated. Parameters such as the x-ray energy, sample-to-detector distance and data processing methods were tested, evaluated and optimized with respect to the estimated diagnostic value using a mastectomy sample with a malignant lesion. The results of quantitative evaluation of images were obtained by means of radiological assessment carried out by 13 experienced specialists. A comparative analysis was performed between the x-ray and the histological images of the specimen. The results of the analysis indicate that, within the investigated range of parameters, both the objective image quality characteristics and the subjective radiological scores of propagation-based phase-contrast images of breast tissues monotonically increase with the strength of phase contrast which in turn is directly proportional to the product of the radiation wavelength and the sample-to-detector distance. The outcomes of this study serve to define the practical imaging conditions and the CT reconstruction procedures appropriate for low-dose phase-contrast mammographic imaging of live patients at specially designed synchrotron beamlines.
引用
收藏
页码:2315 / 2332
页数:18
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