Development and Clinical Implementation of a Universal Bolus to Maintain Spot Size During Delivery of Base of Skull Pencil Beam Scanning Proton Therapy

被引:34
作者
Both, Stefan [1 ]
Shen, Jiajian [1 ,2 ]
Kirk, Maura [1 ]
Lin, Liyong [1 ]
Tang, Shikui [1 ]
Alonso-Basanta, Michelle [1 ]
Lustig, Robert [1 ]
Lin, Haibo [1 ]
Deville, Curtiland [1 ]
Hill-Kayser, Christine [1 ]
Tochner, Zelig [1 ]
McDonough, James [1 ]
机构
[1] Univ Penn, Dept Radiat Oncol, Philadelphia, PA 19104 USA
[2] Mayo Clin, Dept Radiat Oncol, Phoenix, AZ USA
来源
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS | 2014年 / 90卷 / 01期
关键词
D O I
10.1016/j.ijrobp.2014.05.005
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: To report on a universal bolus (UB) designed to replace the range shifter (RS); the UB allows the treatment of shallow tumors while keeping the pencil beam scanning (PBS) spot size small. Methods and Materials: Ten patients with brain cancers treated from 2010 to 2011 were planned using the PBS technique with bolus and the RS. In-air spot sizes of the pencil beam were measured and compared for 4 conditions (open field, with RS, and with UB at 2- and 8-cm air gap) in isocentric geometry. The UB was applied in our clinic to treat brain tumors, and the plans with UB were compared with the plans with RS. Results: A UB of 5.5 cm water equivalent thickness was found to meet the needs of the majority of patients. By using the UB, the PBS spot sizes are similar with the open beam (P>.1). The heterogeneity index was found to be approximately 10% lower for the UB plans than for the RS plans. The coverage for plans with UB is more conformal than for plans with RS; the largest increase in sparing is usually for peripheral organs at risk. Conclusions: The integrity of the physical properties of the PBS beam can be maintained using a UB that allows for highly conformal PBS treatment design, even in a simple geometry of the fixed beam line when noncoplanar beams are used. (C) 2014 Published by Elsevier Inc.
引用
收藏
页码:79 / 84
页数:6
相关论文
共 11 条
[1]   Therapeutic step and shoot proton beam spot-scanning with a multi-leaf collimator: A Monte Carlo study [J].
Bues, M ;
Newhauser, WD ;
Titt, U ;
Smith, AR .
RADIATION PROTECTION DOSIMETRY, 2005, 115 (1-4) :164-169
[2]  
Delaney TF., 2008, Proton and Charged Particle Radiotherapy
[3]   Quality assurance of proton beams using a multilayer ionization chamber system [J].
Dhanesar, Sandeep ;
Sahoo, Narayan ;
Kerr, Matthew ;
Taylor, M. Brad ;
Summers, Paige ;
Zhu, X. Ronald ;
Poenisch, Falk ;
Gillin, Michael .
MEDICAL PHYSICS, 2013, 40 (09)
[4]   Commissioning of the discrete spot scanning proton beam delivery system at the University of Texas MD Anderson Cancer Center, Proton Therapy Center, Houston [J].
Gillin, Michael T. ;
Sahoo, Narayan ;
Bues, Martin ;
Ciangaru, George ;
Sawakuchi, Gabriel ;
Poenisch, Falk ;
Arjomandy, Bijan ;
Martin, Craig ;
Titt, Uwe ;
Suzuki, Kazumichi ;
Smith, Alfred R. ;
Zhu, X. Ronald .
MEDICAL PHYSICS, 2010, 37 (01) :154-163
[5]   MULTIPLE COULOMB SCATTERING OF 160 MEV PROTONS [J].
GOTTSCHALK, B ;
KOEHLER, AM ;
SCHNEIDER, RJ ;
SISTERSON, JM ;
WAGNER, MS .
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION B-BEAM INTERACTIONS WITH MATERIALS AND ATOMS, 1993, 74 (04) :467-490
[6]  
Janni J. F., 1982, Atomic Data and Nuclear Data Tables, V27, P147, DOI 10.1016/0092-640X(82)90004-3
[7]   Preliminary evaluation of multifield and single-field optimization for the treatment planning of spot-scanning proton therapy of head and neck cancer [J].
Quan, Enzhuo M. ;
Liu, Wei ;
Wu, Richard ;
Li, Yupeng ;
Frank, Steven J. ;
Zhang, Xiaodong ;
Zhu, X. Ronald ;
Mohan, Radhe .
MEDICAL PHYSICS, 2013, 40 (08)
[8]   Comparison between the lateral penumbra of a collimated double-scattered beam and uncollimated scanning beam in proton radiotherapy [J].
Safai, Sairos ;
Bortfeld, Thomas ;
Engelsman, Martijn .
PHYSICS IN MEDICINE AND BIOLOGY, 2008, 53 (06) :1729-1750
[9]   Proton dose calculation based on in-air fluence measurements [J].
Schaffner, Barbara .
PHYSICS IN MEDICINE AND BIOLOGY, 2008, 53 (06) :1545-1562
[10]   Adjustment of the lateral and longitudinal size of scanned proton beam spots using a pre-absorber to optimize penumbrae and delivery efficiency [J].
Titt, Uwe ;
Mirkovic, Dragan ;
Sawakuchi, Gabriel O. ;
Perles, Luis A. ;
Newhauser, Wayne D. ;
Taddei, Phillip J. ;
Mohan, Radhe .
PHYSICS IN MEDICINE AND BIOLOGY, 2010, 55 (23) :7097-7106