Outcome of Third Renal Allograft Retransplants Versus Primary Transplants from Paired Donors

被引:13
作者
Horovitz, David [2 ]
Caumartin, Yves [2 ,3 ]
Warren, Jeff [1 ,4 ]
Sheikh, Adeel A. [5 ]
Bloch, Michael [1 ]
Kapoor, Anil [5 ]
Jevnikar, Anthony M. [1 ,6 ]
Luke, Patrick P. W. [1 ,2 ]
机构
[1] London Hlth Sci Ctr, Multiorgan Transplant Program, London, ON N6A 5A5, Canada
[2] Univ Western Ontario, Dept Surg, Div Urol, London, ON, Canada
[3] Univ Western Ontario, Dept Surg, Div Gen Surg, London, ON, Canada
[4] Univ Ottawa, Dept Surg, Div Urol, Ottawa, ON, Canada
[5] McMaster Univ, Dept Surg, Div Urol, Hamilton, ON L8S 4L8, Canada
[6] Univ Western Ontario, Dept Med, Div Nephrol & Immunol, London, ON, Canada
关键词
Retransplantation; Kidney transplantation; Complications; DELAYED GRAFT FUNCTION; RISK-FACTORS; KIDNEY RETRANSPLANTATION; UNITED-STATES; REPEAT TRANSPLANTATION; SINGLE-CENTER; SURVIVAL; RECIPIENTS; MORTALITY; 1ST;
D O I
10.1097/TP.0b013e31819f0f5c
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. Third kidney retransplants have technical and immunologic hurdles that may preclude success, which is of particular importance in the contemporary context of discrepancy between organ supply and demand. Methods. The outcomes of third renal transplant recipients (TRTR) were compared with those receiving a first transplant from paired donor kidneys to assess transplant success and complication rates. The Ontario-based Trillium Gift of Life Network database was used to identify deceased donors (n=28) who donated one kidney to a TRTR and the mate kidney to a primary renal transplant recipient (PRTR) from June 1977 to August 2006. Results. As anticipated, TRTR were sensitized versus PRTR based on % panel reactive antibodies (24%+/- 34% vs. 7%+/- 14%, P=0.03). Delayed graft function (46% vs. 22%, P=0.05) and biopsy-proven rejection episodes (50% vs. 29%, P=0.01) occurred more frequently with TRTR despite greater frequency of induction therapy (74% vs. 35%, P=0.004). However, 1- and 5-year patient survival were similar at 93%, 83% and 96%, 87% for TRTR and PRTR, respectively. Accordingly, 1- and 5-year allograft survival censored for mortality, were comparable at 78%, 66% and 78%, 75%. Renal function was similar in both groups. Bacterial infections (43% vs. 18%, P=0.001) and wound problems (28% vs. 11%, P=0.09) were the only postoperative complications to occur more frequently in the TRTR. Conclusion. We conclude that third renal transplantation should not be discouraged based on functional outcomes alone.
引用
收藏
页码:1214 / 1220
页数:7
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