Recent advances in stimuli-responsive drug release and targeting concepts using mesoporous silica nanoparticles

被引:44
作者
Abdo, Ghada G. [1 ]
Zagho, Moustafa M. [2 ]
Khalil, Ashraf [1 ]
机构
[1] Qatar Univ, Coll Pharm, QU Hlth, POB 2713, Doha, Qatar
[2] Univ Southern Mississippi, Sch Polymer Sci & Engn, Hattiesburg, MS 39406 USA
关键词
Mesoporous silica nanoparticles; Drug delivery; Endogenous and exogenous stimuli; Anticancer drug delivery; Targeting;
D O I
10.1007/s42247-020-00109-x
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Being a developed and promising approach, nanotechnology has attracted a lot of attention in biomedical and pharmaceutical therapy applications. Among nanostructured materials, mesoporous silica nanoparticles (MSNs) are effectively used as nanocarriers for drug delivery systems. MSNs can be tailored-designed by different synthetic techniques. Their morphological characteristics dictate the type of application of such materials. Recently, polymer-based materials have been employed to functionalize the MSNs surface. These modified nanocarriers are loaded with the drug and can unload their "cargo" upon exposure to either endogenous or exogenous types of stimuli. In this study, different targeting concepts, including passive, active, vascular, nuclear, and multistage targeting, are discussed.
引用
收藏
页码:407 / 425
页数:19
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