Perspective Piece Emerging Filoviral Disease in Uganda: Proposed Explanations and Research Directions

被引:15
作者
Polonsky, Jonathan A. [1 ]
Wamala, Joseph F. [2 ]
de Clerck, Hilde [3 ]
Van Herp, Michel [4 ]
Sprecher, Armand [5 ]
Porten, Klaudia [1 ]
Shoemaker, Trevor [6 ]
机构
[1] Epicentre, Intervent Epidemiol & Training Dept, F-75012 Paris, France
[2] Minist Hlth, Epidemiol Surveillance Div, Kampala, Uganda
[3] Medecins Sans Frontieres Operat Ctr Brussels, Brussels, Belgium
[4] Medecins Sans Frontieres Operat Ctr Brussels, Dis Control Unit, Brussels, Belgium
[5] Medecins Sans Frontieres Operat Ctr Brussels, Publ Hlth Unit, Brussels, Belgium
[6] US Ctr Dis Control & Prevent, Viral Special Pathogens Branch, Entebbe, Uganda
关键词
MARBURG HEMORRHAGIC-FEVER; EBOLA; OUTBREAK; VIRUSES;
D O I
10.4269/ajtmh.13-0374
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Outbreaks of Ebola and Marburg virus diseases have recently increased in frequency in Uganda. This increase is probably caused by a combination of improved surveillance and laboratory capacity, increased contact between humans and the natural reservoir of the viruses, and fluctuations in viral load and prevalence within this reservoir. The roles of these proposed explanations must be investigated in order to guide appropriate responses to the changing epidemiological profile. Other African settings in which multiple filoviral outbreaks have occurred could also benefit from such information.
引用
收藏
页码:790 / 793
页数:4
相关论文
共 25 条
[1]   Outbreak of Marburg Hemorrhagic Fever Among Miners in Kamwenge and Ibanda Districts, Uganda, 2007 [J].
Adjemian, Jennifer ;
Farnon, Eileen C. ;
Tschioko, Florimond ;
Wamala, Joseph F. ;
Byaruhanga, Emmanuel ;
Bwire, Godfrey S. ;
Kansiime, Edgar ;
Kagirita, Atek ;
Ahimbisibwe, Sam ;
Katunguka, F. ;
Jeffs, Ben ;
Lutwama, Julius J. ;
Downing, Robert ;
Tappero, Jordan W. ;
Formenty, Pierre ;
Amman, Brian ;
Manning, Craig ;
Towner, Jonathan ;
Nichol, Stuart T. ;
Rollin, Pierre E. .
JOURNAL OF INFECTIOUS DISEASES, 2011, 204 :S796-S799
[2]   Seasonal Pulses of Marburg Virus Circulation in Juvenile Rousettus aegyptiacus Bats Coincide with Periods of Increased Risk of Human Infection [J].
Amman, Brian R. ;
Carroll, Serena A. ;
Reed, Zachary D. ;
Sealy, Tara K. ;
Balinandi, Stephen ;
Swanepoel, Robert ;
Kemp, Alan ;
Erickson, Bobbie Rae ;
Comer, James A. ;
Campbell, Shelley ;
Cannon, Deborah L. ;
Khristova, Marina L. ;
Atimnedi, Patrick ;
Paddock, Christopher D. ;
Crockett, Rebekah J. Kent ;
Flietstra, Timothy D. ;
Warfield, Kelly L. ;
Unfer, Robert ;
Katongole-Mbidde, Edward ;
Downing, Robert ;
Tappero, Jordan W. ;
Zaki, Sherif R. ;
Rollin, Pierre E. ;
Ksiazek, Thomas G. ;
Nichol, Stuart T. ;
Towner, Jonathan S. .
PLOS PATHOGENS, 2012, 8 (10)
[3]   Ebola haemorrhagic fever outbreak in Masindi District, Uganda: outbreak description and lessons learned [J].
Borchert, Matthias ;
Mutyaba, Imaam ;
Van Kerkhove, Maria D. ;
Lutwama, Julius ;
Luwaga, Henry ;
Bisoborwa, Geoffrey ;
Turyagaruka, John ;
Pirard, Patricia ;
Ndayimirije, Nestor ;
Roddy, Paul ;
Van der Stuyft, Patrick .
BMC INFECTIOUS DISEASES, 2011, 11
[4]  
Centers for Disease Control and Prevention, 2012, OUTBR POST
[5]  
Centers for Disease Control and Prevention, 2010, MMWR-MORBID MORTAL W, V303, P413
[6]  
Centers for Disease Control and Prevention (CDC), 2005, MMWR Morb Mortal Wkly Rep, V54, P308
[7]  
Hewlett BS, 2003, EMERG INFECT DIS, V9, P1242
[8]  
Leroy E, 2011, Med Trop (Mars), V71, P111
[9]   Fruit bats as reservoirs of Ebola virus [J].
Leroy, EM ;
Kumulungui, B ;
Pourrut, X ;
Rouquet, P ;
Hassanin, A ;
Yaba, P ;
Délicat, A ;
Paweska, JT ;
Gonzalez, JP ;
Swanepoel, R .
NATURE, 2005, 438 (7068) :575-576
[10]   Human Ebola Outbreak Resulting from Direct Exposure to Fruit Bats in Luebo, Democratic Republic of Congo, 2007 [J].
Leroy, Eric M. ;
Epelboin, Alain ;
Mondonge, Vital ;
Pourrut, Xavier ;
Gonzalez, Jean-Paul ;
Muyembe-Tamfum, Jean-Jacques ;
Formenty, Pierre .
VECTOR-BORNE AND ZOONOTIC DISEASES, 2009, 9 (06) :723-728