Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements

被引：56

作者：

Parameswaran, Krishnan R. ^{[1
]}

Rosen, David I. ^{[1
]}

Allen, Mark G. ^{[1
]}

Ganz, Alan M. ^{[2
]}

Risby, Terence H. ^{[3
]}

机构：

[1] Phys Sci Inc, Andover, MA 01810 USA

[2] Instrumental Solut LLC, Scarsdale, NY 10583 USA

[3] Johns Hopkins Univ, Baltimore, MD 21205 USA

来源：

APPLIED OPTICS | 2009年 / 48卷 / 04期

关键词：

EXHALED ETHANE; SPECTROMETER; SENSITIVITY;

D O I：

10.1364/AO.48.000B73

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has the potential for broad clinical application. We present a simple, compact system using off axis integrated cavity output spectroscopy with an interband cascade laser and demonstrate its use in real-time measurements of breath ethane. We demonstrate a detection sensitivity of 0.48 ppb/Hz(1/2). (C) 2008 Optical Society of America

引用

页码：B73 / B79

页数：7

共 20 条

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