Interactive effects of fitness and hormone treatment on brain health in postmenopausal women

被引：104
作者：
Erickson, Kirk I.
Colcombe, Stanley J.
Elavsky, Steriani
McAuley, Edward
Korol, Donna L.
Scalf, Paige E.
Kramer, Arthur F.
机构：
[1] Univ Illinois, Beckman Inst Adv Sci & Technol, Urbana, IL 61801 USA
[2] Univ Illinois, Dept Psychol, Champaign, IL 61820 USA
[3] Univ Illinois, Dept Kinesiol, Urbana, IL 61801 USA
来源：
NEUROBIOLOGY OF AGING | 2007年 / 28卷 / 02期
关键词：
hormones; estrogen; executive function; aging; brain; prefrontal cortex; fitness; exercise;
D O I：
10.1016/j.neurobiolaging.2005.11.016
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Recent research in rodents Suggests that extended and chronic hormone therapy can exacerbate memory impairments and irreversibly damage cells. However, aerobic fitness regimens have been shown to spare brain tissue and cognitive function. In addition, interactions between estrogen treatment and exercise have been reported in rodents. However, whether aerobic fitness and hormone treatments show interactive effects on human brain tissue and cognition has yet to he determined. Here we report two unique and important results: (a) HRT treatment up to 10 years in duration spares,ray matter in prefrontal cortex and is associated with better performance on measures of executive function, whereas HRT treatment beyond 10 years in duration increases the degree of prefrontal deterioration and amplifies the decline on measures of executive functioning (b) higher fitness levels augment the effects of shorter durations of hormone treatment and ameliorate the declines associated with prolonged hormone treatment. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：179 / 185
页数：7
相关论文
共 36 条
[1]   Voxel-based morphometry - The methods [J].
Ashburner, J ;
Friston, KJ .
NEUROIMAGE, 2000, 11 (06) :805-821
[2]   Effects of cognitive training interventions with older adults - A randomized controlled trial [J].
Ball, K ;
Berch, DB ;
Helmers, KF ;
Jobe, JB ;
Leveck, MD ;
Marsiske, M ;
Morris, JN ;
Rebok, GW ;
Smith, DM ;
Tennstedt, SL ;
Unverzagt, FW ;
Willis, SL .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2002, 288 (18) :2271-2281
[3]   Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus [J].
Berchtold, NC ;
Kesslak, JP ;
Pike, CJ ;
Adlard, PA ;
Cotman, CW .
EUROPEAN JOURNAL OF NEUROSCIENCE, 2001, 14 (12) :1992-2002
[4]   Hormone replacement therapy and reduced cognitive decline in older women - The Cache County Study [J].
Carlson, MC ;
Zandi, PP ;
Plassman, BL ;
Tschanz, JT ;
Welsh-Bohmer, KA ;
Steffens, DC ;
Bastian, LA ;
Mehta, KM ;
Breitner, JCS .
NEUROLOGY, 2001, 57 (12) :2210-2216
[5]   Fitness effects on the cognitive function of older adults: A meta-analytic study [J].
Colcombe, S ;
Kramer, AF .
PSYCHOLOGICAL SCIENCE, 2003, 14 (02) :125-130
[6]   Cardiovascular fitness, cortical plasticity, and aging [J].
Colcombe, SJ ;
Kramer, AF ;
Erickson, KI ;
Scalf, P ;
McAuley, E ;
Cohen, NJ ;
Webb, A ;
Jerome, GJ ;
Marquez, DX ;
Elavsky, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (09) :3316-3321
[7]  
Colcombe SJ, 2003, J GERONTOL A-BIOL, V58, P176
[8]   Exercise: a behavioral intervention to enhance brain health and plasticity [J].
Cotman, CW ;
Berchtold, NC .
TRENDS IN NEUROSCIENCES, 2002, 25 (06) :295-301
[9]   The women's health initiative memory study: findings and implications for treatment [J].
Craig, MC ;
Maki, PM ;
Murphy, DGM .
LANCET NEUROLOGY, 2005, 4 (03) :190-194
[10]   Selective sparing of brain tissue in postmenopausal women receiving hormone replacement therapy [J].
Erickson, KI ;
Colcombe, SJ ;
Raz, N ;
Korol, DL ;
Scalf, P ;
Webb, A ;
Cohen, NJ ;
McAuley, E ;
Kramer, AF .
NEUROBIOLOGY OF AGING, 2005, 26 (08) :1205-1213
1234