Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard

被引：63

作者：

Lockhart, Shawn R. ^{[1
]}

Ghannoum, Mahmoud A. ^{[2
,3
]}

Alexander, Barbara D. ^{[4
,5
,6
,7
]}

机构：

[1] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA

[2] Univ Hosp Cleveland, Med Ctr, Ctr Med Mycol, Cleveland, OH 44106 USA

[3] Case Western Reserve Univ, Cleveland, OH 44106 USA

[4] Duke Univ, Dept Med, Div Infect Dis & Int Hlth, Durham, NC USA

[5] Duke Univ, Dept Med, Clin Microbiol Lab, Durham, NC USA

[6] Duke Univ, Dept Pathol, Div Infect Dis & Int Hlth, Durham, NC 27706 USA

[7] Duke Univ, Dept Pathol, Clin Microbiol Lab, Durham, NC 27706 USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2017年 / 55卷 / 05期

关键词：

ECV; breakpoint; epidemiological cutoff value; BROTH MICRODILUTION METHOD; METHOD M38-A2 DOCUMENT; GATTII SPECIES COMPLEX; MIC DISTRIBUTIONS; CRYPTOCOCCUS-NEOFORMANS; ASPERGILLUS SPP; AMPHOTERICIN-B; CANDIDA SPP; POSACONAZOLE; MULTICENTER;

D O I：

10.1128/JCM.02416-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Breakpoints are used to predict whether an antifungal agent will be clinically effective against a particular fungal isolate. They are based on a combination of MIC values, pharmacokinetic/pharmacodynamic values, and clinical outcome data. For many fungus-antifungal combinations, these data might never be available. For these combinations, epidemiological cutoff values (ECVs) provide a methodology for categorizing isolates as either wild type (WT) or non-WT. In this review, we define ECVs, explain how they are generated using the CLSI methodology in standard M57, and describe how they can be used in clinical practice.

引用

页码：1262 / 1268

页数：7

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