Is the pregnancy hormone relaxin also a vasodilator peptide secreted by the heart?

被引：86
作者：
Fisher, C
MacLean, M
Morecroft, I
Seed, A
Johnston, F
Hillier, C
McMurray, J
机构：
[1] Univ Glasgow, Dept Med & Therapeut, Glasgow G12 8QQ, Lanark, Scotland
[2] Univ Glasgow, Div Neurosci & Biomed Syst, Glasgow G12 8QQ, Lanark, Scotland
[3] Univ Glasgow, Inst Biomed & Life Sci, Div Neurosci & Biomed Syst, Glasgow G12 8QQ, Lanark, Scotland
[4] Glasgow Caledonian Univ, Vasc Assessment Grp, Glasgow G4 0BA, Lanark, Scotland
来源：
CIRCULATION | 2002年 / 106卷 / 03期
关键词：
vasodilation; arteries; endothelium; peptides;
D O I：
10.1161/01.CIR.0000025630.05387.45
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Background-It has been shown recently that the pregnancy and parturition hormone, relaxin, is secreted by the heart. This study examined the effects of relaxin in small human resistance arteries from the systemic and pulmonary circulations. Methods and Results-Arteries were obtained from gluteal biopsies and resected lung tissue and studied with the use of wire myography. Cumulative concentration relaxation curves were constructed in systemic arteries with substance P, epoprostenol, atrial natriuretic peptide, and relaxin (concentration range 10(-13)-10(-7)M). The maximal responses were 88(+/-5)%, 67(+/-10)%, 52(+/-16)% and 66(+/-16)%, respectively. Endothelium removal virtually abolished the action of relaxin. Relaxin had no vasodilator effect in pulmonary arteries. Conclusions-Relaxin is a powerful dilator of systemic resistance arteries secreted by the heart that may contribute to cardiovascular regulation.
引用
收藏
页码：292 / 295
页数：4
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