Interaction of NK Cells, Trophoblast, and Endothelial Cells during Angiogenesis

被引：7
作者：
Belyakova, K. L. [1 ]
Stepanova, O. I. [1 ]
Sheveleva, A. R. [1 ]
Mikhailova, V. A. [1 ]
Sokolov, D. I. [1 ]
Sel'kov, S. A. [1 ]
机构：
[1] DO Ott Res Inst Obstet Gynecol & Reproductol, St Petersburg, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2019年 / 167卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
trophoblast; natural killer cells; endothelial cells; cytokines; angiogenesis; NATURAL-KILLER-CELLS; STROMAL CELLS; EXPRESSION;
D O I：
10.1007/s10517-019-04484-2
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied changes in angiogenesis during contact interaction of natural killer cells and endothelial cells in the presence of secretory products of trophoblast cells activated by various cytokines. Activated trophoblast regulates angiogenesis by producing soluble factors that affect endothelial cells either directly or indirectly through activation of proangiogenic activity of natural killer cells. A stimulating effect of the trophoblast supernatants activated by IL-1 and an inhibitory effect of trophoblast supernatants activated by IL-6 and TGF for the formation of tube-like structures by endothelial cells were revealed. During contact culturing, natural killer cells increased the length of tube-like structures formed by endothelial cells. The trophoblast activated by IL-1 affects angiogenesis both directly through the production of proangiogenic factors and indirectly through activation of the proangiogenic potential of natural killer cells. Trophoblast activated by IFN affects angiogenesis only by stimulating the proangiogenic potential of natural killer cells. Under conditions of contact interaction of natural killer cells and endothelial cells, soluble factors of trophoblast activated by IL-6 or TGF attenuated the angiogenesis-stimulating effect of natural killer cells.
引用
收藏
页码：169 / 176
页数：8
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