Regulation of vesicular transport by membrane curvature

被引:1
|
作者
Drin, Guillaume
Bigay, Joelle
Antonny, Bruno [1 ]
机构
[1] Univ Nice Sophia Antipolis, Inst Pharmacol Mol & Cellulaire, UMR 6097, F-06560 Valbonne, France
来源
M S-MEDECINE SCIENCES | 2009年 / 25卷 / 05期
关键词
COPII VESICLE; GOLGI-APPARATUS; COAT; FISSION; ARFGAP1; DOMAINS; ORGANIZATION; MECHANISMS; PROTEINS; FUSION;
D O I
10.1051/medsci/2009255483
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
A cellular membrane is highly deformable: during the last decade, numerous studies have dissected at the molecular scale how during vesicular transport various proteins could deform a membrane or recognize membrane deformation. We will discuss how the activity of ArfGAP1 and GMAP-210, two proteins involved in vesicular transport, is regulated by membrane curvature thanks to an ALPS motif. Since a membrane is not solely defined by its shape but also by its lipids composition, we will show how others proteins are adapted to other lipid compositions to recognize membrane shape.
引用
收藏
页码:483 / 488
页数:6
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