Iso-α-acids, bitter components of beer, prevent obesity-induced cognitive decline

被引：32

作者：

Ayabe, Tatsuhiro ^{[1
]}

Ohya, Rena ^{[1
]}

Kondo, Keiji ^{[1
]}

Ano, Yasuhisa ^{[1
]}

机构：

[1] Kirin Co Ltd, Res Labs Hlth Sci & Food Technol, Yokohama, Kanagawa 2360004, Japan

来源：

SCIENTIFIC REPORTS | 2018年 / 8卷

关键词：

STIMULATED PROINFLAMMATORY RESPONSES; RECEPTOR-GAMMA; LIPID-PEROXIDATION; ALZHEIMERS-DISEASE; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; ROSIGLITAZONE; ISOHUMULONES; INFLAMMATION; BRAIN;

D O I：

10.1038/s41598-018-23213-9

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dementia and cognitive decline have become worldwide public health problems, and it was recently reported that life-style related diseases and obesity are key risk factors in dementia. Iso-alpha-acids, hop-derived bitter components of beer, have been reported to have various physiological functions via activation of peroxisome proliferator-activated receptor gamma. In this report, we demonstrated that daily intake of iso-alpha-acids suppresses inflammations in the hippocampus and improves cognitive decline induced by high fat diet (HFD). Body weight, epididymal fat weight, and plasma triglyceride levels were increased in HFD-fed mice, and significantly decreased in iso-alpha-acids supplemented HFD-fed mice. HFD feeding enhances the production of inflammatory cytokines and chemokines, such as TNF-alpha, which was significantly suppressed by iso-alpha-acids administration. HFD-induced neuroinflammation caused lipid peroxidation, neuronal loss, and atrophy in hippocampus, and those were not observed in iso-alpha-acids-treated mice. Furthermore, iso-alpha-acids intake significantly improved cognitive decline induced by HFD-feeding. Iso-alpha-acids are food derived components that suppressing both lipid accumulation and brain inflammation, thus iso-alpha-acids might be beneficial for the risk of dementia increased by obesity and lifestyle-related diseases.

引用

页数：9

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