Immunotherapy Targeting Tumor-Associated Macrophages

被引：19

作者：

Liu, Yafei ^{[1
]}

Wang, Rongsi ^{[2
]}

机构：

[1] China Med Univ, Affiliat Hosp 4, Dept Pharm, Shenyang, Peoples R China

[2] East China Normal Univ, High Sch, Shanghai, Peoples R China

来源：

FRONTIERS IN MEDICINE | 2020年 / 7卷

关键词：

macrophage; tumor microenvironment; cancer; immunotherapy; polarization; FUNCTIONAL POLARIZATION; THERAPEUTIC RESISTANCE; PANCREATIC-CANCER; SUPPRESSOR-CELLS; SIGNALING AXIS; MYELOID CELLS; ACTIVATION; METASTASIS; INHIBITION; EXPRESSION;

D O I：

10.3389/fmed.2020.583708

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Macrophages are phagocytic cells that play a broad role in maintaining body homeostasis and defense against foreign pathogens; whereas tumor-associated macrophages (TAMs) support tumor growth and metastasis by promoting cancer cell proliferation and invasion, immunosuppression, and angiogenesis, which is closely related to the poor prognosis in almost all solid tumors. Hence, deep-insight knowledge into TAMs can provide an opportunity to discover more effective strategies for cancer therapeutics. So far, a large number of therapeutic agents targeting TAMs are in clinical trials. In this review, we introduce an extensive overview about macrophages and macrophage-targeting agents.

引用

页数：11

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