Interactions of Phenanthroline Compounds with i-Motif DNA

被引：7
|
作者：
Gao Ning [1 ]
Wang Yanbo [1 ]
Wei Chunying [1 ]
机构：
[1] Shanxi Univ, Inst Mol Sci, Minist Educ, Key Lab Chem Biol & Mol Engn, Taiyuan 030006, Peoples R China
来源：
CHEMICAL RESEARCH IN CHINESE UNIVERSITIES | 2014年 / 30卷 / 03期
基金：
中国国家自然科学基金; 高等学校博士学科点专项科研基金;
关键词：
i-Motif DNA; Phenanthroline derivative; Interaction; HUMAN TELOMERIC DNA; G-QUADRUPLEX DNAS; PROXIMAL PROMOTER; COMPLEXES; PORPHYRIN; BINDING; DUPLEX; GENE; RICH; PH;
D O I：
10.1007/s40242-014-3391-9
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The interactions of each of three phenanthroline derivatives 1, 2 and 3 with the human telomeric i-motif DNA were investigated. The results suggest these compounds are potent binders. The compounds could stabilize the structure of i-motif DNA by pi-pi stacking. Moreover, the binding constants of the compounds with i-motif DNA were (2.71-8.12)x10(4) L.mol(-1), and the binding stoichiometry ratio was 1:1. CD studies reveal that the binding by phenanthroline compounds perturbs the conformation of i-motif DNA.
引用
收藏
页码：495 / 499
页数：5
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