Elevated mutation rates in the germline of Polκ mutant male mice

被引：25

作者：

Burr, Karen L-A

Velasco-Miguel, Susana

Duvvuri, Venkata S.

McDaniel, Lisa D.

Friedberg, Errol C.

Dubrova, Yuri E.

机构：

[1] Univ Leicester, Dept Genet, Leicester LE1 7RH, Leics, England

[2] Univ Texas, SW Med Ctr, Dept Pathol, Lab Mol Pathol, Dallas, TX 75390 USA

来源：

DNA REPAIR | 2006年 / 5卷 / 07期

关键词：

DNA polymerase kappa; expanded simple tandem repeat loci; germline mutation; mice;

D O I：

10.1016/j.dnarep.2006.04.003

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Mutation rates at two expanded simple tandem repeat (ESTR) loci were studied in the germline of DNA polymerase kappa (POl kappa(-/-)) deficient mice. The spontaneous mutation rate in homozygous POl kappa(-/-) males was significantly higher than in isogenic wild-type mice (POl kappa(-/-)), but the ESTR mutation spectrum in POl kappa(-/-) animals did not differ from that in POl kappa(+/+) males. We suggest that compromised translesion synthesis in POl kappa(-/-) mice may result in replication fork pausing which, in turn, may affect ESTR mutation rate. (c) 2006 Elsevier B.V. All rights reserved.

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收藏

页码：860 / 862

页数：3

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