Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization

被引:29
作者
Arneja, Abhinav [1 ]
Salazar, Juan E. [1 ]
Jiang, Wenyu [2 ]
Hendrickson, Jeanne E. [3 ,4 ]
Zimring, James C. [5 ,6 ,7 ]
Luckey, Chance John [1 ]
机构
[1] Univ Virginia, Dept Pathol, Charlottesville, VA 22903 USA
[2] Brigham & Womens Hosp, Dept Pathol, 75 Francis St, Boston, MA 02115 USA
[3] Yale Univ, Dept Lab Med, New Haven, CT USA
[4] Yale Univ, Dept Pediat, New Haven, CT 06520 USA
[5] Univ Washington, Sch Med, Bloodworks NW Res Inst, Seattle, WA USA
[6] Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA
[7] Univ Washington, Sch Med, Dept Med, Div Hematol, Seattle, WA 98195 USA
关键词
IL-6R expression; RBC alloimmunization; T-follicular helper cell differentiation; RESPONSES; STORAGE; IL-6;
D O I
10.3324/haematol.2016.149278
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E440 / E444
页数:5
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