Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

被引：9
作者：
Healey, KM
Pavletic, SZ
Al-Omaishi, J
Leuschen, MP
Pirruccello, SJ
Filipi, ML
Enke, C
Ursick, MM
Hahn, F
Bowen, JD
Nash, RA
机构：
[1] Univ Nebraska, Med Ctr, Dept Neurol Sci, Omaha, NE USA
[2] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE USA
[3] Univ Nebraska, Med Ctr, Dept Cell Biol & Anat, Omaha, NE USA
[4] Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA
[5] Univ Nebraska, Med Ctr, Dept Radiat Oncol, Omaha, NE USA
[6] Univ Nebraska, Med Ctr, Dept Radiol, Omaha, NE 68105 USA
[7] Univ Washington, Dept Neurol, Seattle, WA 98195 USA
[8] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA
来源：
MULTIPLE SCLEROSIS JOURNAL | 2004年 / 10卷 / 03期
关键词：
autologous stem cell transplantation; functional outcomes; multiple sclerosis;
D O I：
10.1191/1352458504ms1022oa
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.
引用
收藏
页码：284 / 289
页数：6
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