Discordant functional and inflammatory parameters in multiple sclerosis patients after autologous haematopoietic stem cell transplantation

被引：9

作者：

Healey, KM

Pavletic, SZ

Al-Omaishi, J

Leuschen, MP

Pirruccello, SJ

Filipi, ML

Enke, C

Ursick, MM

Hahn, F

Bowen, JD

Nash, RA

机构：

[1] Univ Nebraska, Med Ctr, Dept Neurol Sci, Omaha, NE USA

[2] Univ Nebraska, Med Ctr, Dept Internal Med, Omaha, NE USA

[3] Univ Nebraska, Med Ctr, Dept Cell Biol & Anat, Omaha, NE USA

[4] Univ Nebraska, Med Ctr, Dept Pathol & Microbiol, Omaha, NE USA

[5] Univ Nebraska, Med Ctr, Dept Radiat Oncol, Omaha, NE USA

[6] Univ Nebraska, Med Ctr, Dept Radiol, Omaha, NE 68105 USA

[7] Univ Washington, Dept Neurol, Seattle, WA 98195 USA

[8] Univ Washington, Fred Hutchinson Canc Res Ctr, Seattle, WA 98195 USA

来源：

MULTIPLE SCLEROSIS JOURNAL | 2004年 / 10卷 / 03期

关键词：

autologous stem cell transplantation; functional outcomes; multiple sclerosis;

D O I：

10.1191/1352458504ms1022oa

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This article describes outcomes in four patients with advanced multiple sclerosis up to two years after autologous haematopoietic stem cell transplantation using a total-body irradiation-based preparative regimen. MRI and CSF analyses demonstrated clear suppression of the inflammatory processes. The results demonstrate however, a dissociation of inflammation parameters and functional disability findings raising questions about optimal future stem cell transplantation strategies for this disease.

引用

页码：284 / 289

页数：6

共 23 条

[1] SYNGENEIC BONE-MARROW TRANSPLANTATION ELIMINATES V-BETA-8.2 T-LYMPHOCYTES FROM THE SPINAL-CORD OF LEWIS RATS WITH EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS [J].

BURT, RK ;

BURNS, W ;

RUVOLO, P ;

FISCHER, A ;

SHIAO, C ;

GUIMARAES, A ;

BARRETT, J ;

HESS, A .

JOURNAL OF NEUROSCIENCE RESEARCH, 1995, 41 (04) :526-531

[2] Hematopoietic stem cell transplantation for progressive multiple sclerosis: failure of a total body irradiation-based conditioning regimen to prevent disease progression in patients with high disability scores [J].

Burt, RK ;

Cohen, BA ;

Russell, E ;

Spero, K ;

Joshi, A ;

Oyama, Y ;

Karpus, WJ ;

Luo, KH ;

Jovanovic, B ;

Traynor, A ;

Karlin, K ;

Stefoski, D ;

Burns, WH .

BLOOD, 2003, 102 (07) :2373-2378

[3]

Carreras E, 2003, HAEMATOLOGICA, V88, P306

[4] Development of a multiple sclerosis functional composite as a clinical trial outcome measure [J].

Cutter, GR ;

Baier, ML ;

Rudick, RA ;

Cookfair, DL ;

Fischer, JS ;

Petkau, J ;

Syndulko, K ;

Weinshenker, BG ;

Antel, JP ;

Confavreux, C ;

Ellison, GW ;

Lublin, F ;

Miller, AE ;

Rao, SM ;

Reingold, S ;

Thompson, A ;

Willoughby, E .

BRAIN, 1999, 122 :871-882

[5] Autologous stem cell transplantation in progressive multiple sclerosis - An interim analysis of efficacy [J].

Fassas, A ;

Anagnostopoulos, A ;

Kazis, A ;

Kapinas, K ;

Sakellari, I ;

Kimiskidis, V ;

Smias, C ;

Eleftheriadis, N ;

Tsimourtou, V .

JOURNAL OF CLINICAL IMMUNOLOGY, 2000, 20 (01) :24-30

[6] CHRONIC-RELAPSING EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS (CR-EAE) - TREATMENT AND INDUCTION OF TOLERANCE, WITH HIGH-DOSE CYCLOPHOSPHAMIDE FOLLOWED BY SYNGENEIC BONE-MARROW TRANSPLANTATION [J].

KARUSSIS, DM ;

SLAVIN, S ;

BENNUN, A ;

OVADIA, H ;

VOURKAKARUSSIS, U ;

LEHMANN, D ;

MIZRACHIKOL, R ;

ABRAMSKY, O .

JOURNAL OF NEUROIMMUNOLOGY, 1992, 39 (03) :201-210

[7]

KARUSSIS DM, 1992, J IMMUNOL, V148, P1693

[8] Immunoablative therapy with autologous stem cell transplantation in the treatment of poor risk multiple sclerosis [J].

Kozák, T ;

Havrdová, E ;

Pit'ha, J ;

Gregora, E ;

Pytlík, R ;

Maaloufová, J ;

Kobylka, P ;

Vodvárková, S .

TRANSPLANTATION PROCEEDINGS, 2001, 33 (03) :2179-2181

[9] Hematopoietic stem cell transplantation for multiple sclerosis - A retrospective multicenter study [J].

Kozak, T ;

Havrdova, E ;

Carreras, E ;

Graus, F ;

Kashyap, A ;

Openshaw, H ;

Schipperus, M ;

Deconinck, E ;

Mancardi, G ;

Marmont, A ;

Hansz, J ;

Rabusin, M ;

Nagore, FJZ ;

Besalduch, J ;

Dentamaro, T ;

Fouillard, L ;

Hertenstein, B ;

La Nasa, G ;

Musso, M ;

Papineschi, F ;

Rowe, JM ;

Saccardi, R ;

Passweg, JR ;

Steck, A ;

Kappos, L ;

Gratwohl, A ;

Tyndall, A ;

Fassas, AS ;

Anagnostopoulos, A ;

Kazis, A .

JOURNAL OF NEUROLOGY, 2002, 249 (08) :1088-1097

[10]

KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444

← 1 2 3 →