Integrins and Their Role in Immune Cell Adhesion

被引:40
作者
Dustin, Michael L. [1 ]
机构
[1] Univ Oxford, NDORMS, Kennedy Inst Rheumatol, Oxford OX3 7FY, Oxon, England
关键词
BETA-SUBUNIT; DISTINCT; LFA-1; FIBRONECTIN; DOMAINS;
D O I
10.1016/j.cell.2019.03.038
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
One of the 2019 Canada Gairdner International Awards recognizes Timothy Springer's discovery of the first immune system adhesion molecules involved in lymphocyte homing and the translation of those discoveries into therapeutics for autoimmune disease and cancer.
引用
收藏
页码:499 / 501
页数:3
相关论文
共 50 条
  • [41] Brain endothelial cell specific integrins and ischemic stroke
    Guell, Kathleen
    Bix, Gregory J.
    EXPERT REVIEW OF NEUROTHERAPEUTICS, 2014, 14 (11) : 1287 - 1292
  • [42] Characterization of adhesion properties of the cardiomyocyte integrins and extracellular matrix proteins using atomic force microscopy
    Li, Zecheng
    Liu, Tianqi
    Yang, Junxian
    Lin, Jiangguo
    Xin, Sherman Xuegang
    JOURNAL OF MOLECULAR RECOGNITION, 2020, 33 (04)
  • [43] Relative contributions of α4 and αL Integrins to IL-4-induced leukocyte rolling and adhesion
    Eppihimer, MJ
    Sushkova, N
    Lavigne, MC
    MICROCIRCULATION, 2004, 11 (08) : 655 - 668
  • [44] Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants
    Mostafavi-Pour, Z
    Askari, JA
    Whittard, JD
    Humphries, MJ
    MATRIX BIOLOGY, 2001, 20 (01) : 63 - 73
  • [45] Adhesion molecules during immune response to exercise
    Gabriel, HHW
    Kindermann, W
    CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1998, 76 (05) : 512 - 523
  • [46] Intercellular adhesion molecule-1, intercellular adhesion molecule-3, and leukocyte integrins in leukocyte accumulation in membranoproliferative glomerulonephritis type I
    Soma, J
    Saito, T
    Ootaka, T
    Sato, H
    Abe, K
    AMERICAN JOURNAL OF KIDNEY DISEASES, 1996, 28 (05) : 685 - 694
  • [47] Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migration
    Sieg, DJ
    Hauck, CR
    Schlaepfer, DD
    JOURNAL OF CELL SCIENCE, 1999, 112 (16) : 2677 - 2691
  • [48] Appearance of Tissue Transglutaminase in Astrocytes in Multiple Sclerosis Lesions: A Role in Cell Adhesion and Migration?
    van Strien, Miriam E.
    Drukarch, Benjamin
    Bol, John G.
    van der Valk, Paul
    van Horssen, Jack
    Gerritsen, Wouter H.
    Breve, John J.
    van Dam, Anne-Marie
    BRAIN PATHOLOGY, 2011, 21 (01) : 44 - 54
  • [49] The Janus Role of Adhesion in Chondrogenesis
    Casanellas, Ignasi
    Lagunas, Anna
    Vida, Yolanda
    Perez-Inestrosa, Ezequiel
    Andrades, Jose A.
    Becerra, Jose
    Samitier, Josep
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 21 (15) : 11 - 14
  • [50] FIBRONECTIN RECEPTOR INTEGRINS ARE INVOLVED IN MAST-CELL ACTIVATION
    RA, CS
    YASUDA, M
    YAGITA, H
    OKUMURA, K
    JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 1994, 94 (03) : 625 - 628