Integrins and Their Role in Immune Cell Adhesion

被引：40
作者：
Dustin, Michael L. [1 ]
机构：
[1] Univ Oxford, NDORMS, Kennedy Inst Rheumatol, Oxford OX3 7FY, Oxon, England
来源：
CELL | 2019年 / 177卷 / 03期
关键词：
BETA-SUBUNIT; DISTINCT; LFA-1; FIBRONECTIN; DOMAINS;
D O I：
10.1016/j.cell.2019.03.038
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
One of the 2019 Canada Gairdner International Awards recognizes Timothy Springer's discovery of the first immune system adhesion molecules involved in lymphocyte homing and the translation of those discoveries into therapeutics for autoimmune disease and cancer.
引用
收藏
页码：499 / 501
页数：3
相关论文
共 50 条
  • [21] AFM Force Spectroscopy Reveals the Role of Integrins and Their Activation in Cell-Biomaterial Interactions
    Harjumaki, Riina
    Zhang, Xue
    Nugroho, Robertus Wahyu N.
    Farooq, Muhammad
    Lou, Yan-Ru
    Yliperttula, Marjo
    Valle-Delgado, Juan Jose
    Osterberg, Monika
    ACS APPLIED BIO MATERIALS, 2020, 3 (03): : 1406 - 1417
  • [22] Role of integrins and their ligands in osteoarthritic cartilage
    Tian, Jian
    Zhang, Fang-Jie
    Lei, Guang-Hua
    RHEUMATOLOGY INTERNATIONAL, 2015, 35 (05) : 787 - 798
  • [23] The binding ability to matrix proteins and the inhibitory effects on cell adhesion of synthetic peptides derived from a conserved sequence of integrins
    Liu, YK
    Nemoto, A
    Feng, Y
    Uemura, T
    JOURNAL OF BIOCHEMISTRY, 1997, 121 (05) : 961 - 968
  • [24] Extracellular vesicle integrins act as a nexus for platelet adhesion in cerebral microvessels
    Bagi, Zsolt
    Couch, Yvonne
    Broskova, Zuzana
    Perez-Balderas, Francisco
    Yeo, Tianrong
    Davis, Simon
    Fischer, Roman
    Sibson, Nicola R.
    Davis, Benjamin G.
    Anthony, Daniel C.
    SCIENTIFIC REPORTS, 2019, 9 (1)
  • [25] Beta2-Integrins and Interacting Proteins in Leukocyte Trafficking, Immune Suppression, and Immunodeficiency Disease
    Fagerholm, Susanna C.
    Guenther, Carla
    Asens, Marc Llort
    Savinko, Terhi
    Uotila, Liisa M.
    FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [26] The role of integrins and extracellular matrix in anchorage-independent growth of a mammary carcinoma cell line
    Saulnier, R
    Chan, B
    Uniyal, S
    Chan, T
    Patrzykat, A
    Elliott, BE
    CELLULAR AND MOLECULAR BIOLOGY, 1997, 43 (03) : 455 - 468
  • [27] Identification of an intercellular cell adhesion molecule-1 homologue from grass carp: Evidence for its involvement in the immune cell adhesion in teleost
    Wei, He
    Lv, Mengyuan
    Wen, Chao
    Zhang, Anying
    Yang, Kun
    Zhou, Hong
    Wang, Xinyan
    FISH & SHELLFISH IMMUNOLOGY, 2018, 81 : 67 - 72
  • [28] Role of integrins in the development of fibrosis in the trabecular meshwork
    Faralli, Jennifer A.
    Filla, Mark S.
    Peters, Donna M.
    FRONTIERS IN OPHTHALMOLOGY, 2023, 3
  • [29] The lipoxygenase inhibitor, baicalein, modulates cell adhesion and migration by up-regulation of integrins and vinculin in rat heart endothelial cells
    Hsieh, Y-C S.
    Hsieh, S-J
    Chang, Y-S
    Hsueh, C-M
    Hsu, S-L
    BRITISH JOURNAL OF PHARMACOLOGY, 2007, 151 (08) : 1235 - 1245
  • [30] Resveratrol inhibits ovarian cancer cell adhesion to peritoneal mesothelium in vitro by modulating the production of α5β1 integrins and hyaluronic acid
    Mikula-Pietrasik, Justyna
    Sosinska, Patrycja
    Ksiazek, Krzysztof
    GYNECOLOGIC ONCOLOGY, 2014, 134 (03) : 624 - 630
12345