Red Si-rhodamine drug conjugates enable imaging in GFP cells

被引：42

作者：

Kim, Eunha ^{[1
]}

Yang, Katherine S. ^{[1
]}

Giedt, Randy J. ^{[1
]}

Weissleder, Ralph ^{[1
,2
]}

机构：

[1] Harvard Univ, Sch Med, Ctr Syst Biol, Massachusettes Gen Hosp, Boston, MA 02114 USA

[2] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 34期

基金：

美国国家卫生研究院;

关键词：

SINGLE-CELL; IN-VIVO; LOCALIZATION; MICROSCOPY; PROBE;

D O I：

10.1039/c4cc00144c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Here we evaluated a series of Si-derivatized rhodamine (SiR) dyes for their ability to visualize a model drug in live cells. We show that a charge neutral SiR derivative (but not others) can indeed be used to follow the intracellular location of the model therapeutic drug in GFP cells.

引用

页码：4504 / 4507

页数：4

共 4 条

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