Glyoxal bis(phenylhydrazone) as promoter for CuI-catalyzed O-arylation of phenols with bromoarenes

被引：32

作者：

Liu, Yu-Hua ^{[1
,2
]}

Li, Gang ^{[1
,2
]}

Yang, Lian-Ming ^{[1
]}

机构：

[1] Chinese Acad Sci, New Mat Lab, Inst Chem, BNLMS, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China

来源：

TETRAHEDRON LETTERS | 2009年 / 50卷 / 03期

基金：

中国国家自然科学基金;

关键词：

DIARYL ETHER SYNTHESIS; COUPLING REACTION; ARYL HALIDES; COPPER; LIGAND; NITROGEN; BONDS;

D O I：

10.1016/j.tetlet.2008.11.005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A very simple bishydrazone-type ligand, glyoxal bis(phenylhydrazone) (L1), was found to effectively promote the CuI-catalyzed O-arylation of phenols with aryl bromides. This cross-coupling reaction proceeded in acetonitrile at 60-80 degrees C in the presence of K3PO4 as base. A diverse array of phenols and bromoarenes was employed as Substrates to afford diaryl ethers in good to excellent yields, and some base-sensitive groups, such as ester, aldehyde, and ketone groups, can survive under the mild reaction conditions. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：343 / 346

页数：4

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