Oligonucleotide aptamers against tyrosine kinase receptors: Prospect for anticancer applications

被引：37

作者：

Camorani, Simona ^{[1
]}

Crescenzi, Elvira ^{[1
]}

Fedele, Monica ^{[1
]}

Cerchia, Laura ^{[1
]}

机构：

[1] CNR, Ist Endocrinol Oncol Sperimentale G Salvatore IEO, Via S Pansini 5, I-80131 Naples, Italy

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2018年 / 1869卷 / 02期

关键词：

Aptamer; Cancer diagnosis; Cancer therapy; RTK; SELEX; Targeted delivery; GROWTH-FACTOR RECEPTOR; BREAST-CANCER CELLS; HIGHLY SENSITIVE DETECTION; IN-VITRO SELECTION; RNA APTAMER; DNA APTAMERS; LUNG-CANCER; PDGFR-BETA; TARGETED DELIVERY; IMMOBILIZED APTAMERS;

D O I：

10.1016/j.bbcan.2018.03.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transmembrane receptor tyrosine kinases (RTKs) play crucial roles in cancer cell proliferation, survival, migration and differentiation. Area of intense research is searching for effective anticancer therapies targeting these receptors and, to date, several monoclonal antibodies and small-molecule tyrosine kinase inhibitors have entered the clinic. However, some of these drugs show limited efficacy and give rise to acquired resistance. Emerging highly selective compounds for anticancer therapy are oligonucleotide aptamers that interact with their targets by recognizing a specific three-dimensional structure. Because of their nucleic acid nature, the rational design of advanced strategies to manipulate aptamers for both diagnostic and therapeutic applications is greatly simplified over antibodies. In this manuscript, we will provide a comprehensive overview of oligonucleotide aptamers as next generation strategies to efficiently target RTKs in human cancers.

引用

页码：263 / 277

页数：15

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