Impact of nelfinavir resistance mutations on in vitro phenotype, fitness, and replication capacity of human immunodeficiency virus type 1 with subtype B and C proteases

被引：41

作者：

Gonzalez, LMF ^{[1
]}

Brindeiro, RM ^{[1
]}

Aguiar, RS ^{[1
]}

Pereira, HS ^{[1
]}

Abreu, CM ^{[1
]}

Soares, MA ^{[1
]}

Tanuri, A ^{[1
]}

机构：

[1] Univ Fed Rio de Janeiro, Mol Virol Lab, Dept Genet, BR-21944970 Rio De Janeiro, Brazil

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2004年 / 48卷 / 09期

关键词：

D O I：

10.1128/AAC.48.9.3552-3555.2004

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human immunodeficiency virus type 1 subtype B and C proteases were manipulated to contain 90M, 88D, or 89L, and their in vitro biological properties were studied. We showed that D30N has significantly more impact in subtype C than in subtype B counterparts, accounting for the reported low prevalence of this mutation in patients failing nelfinavir-based regimens.

引用

页码：3552 / 3555

页数：4

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