Palladium-Catalyzed Cascade Annulation To Construct Functionalized β- and γ-Lactones in Ionic Liquids

被引：99

作者：

Li, Jianxiao ^{[1
]}

Yang, Wanfei ^{[1
]}

Yang, Shaorong ^{[1
]}

Huang, Liangbin ^{[1
]}

Wu, Wanqing ^{[1
]}

Sun, Yadong ^{[1
]}

Jiang, Huanfeng ^{[1
]}

机构：

[1] S China Univ Technol, Sch Chem & Chem Engn, Guangzhou 510640, Guangdong, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2014年 / 53卷 / 28期

基金：

中国国家自然科学基金;

关键词：

alkynes; annulation; ionic liquids; lactones; palladium; ENANTIOSELECTIVE SYNTHESIS; DENITROGENATIVE ANNULATION; EFFICIENT SYNTHESIS; CONJUGATE ADDITION; COUPLING REACTIONS; ACTIVATED ALKENES; FORMAL SYNTHESIS; PARACONIC ACIDS; ARYL HALIDES; BOND;

D O I：

10.1002/anie.201403341

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and mild palladium-catalyzed, one-pot, four-step cascade annulation has been developed to afford functionalized beta- and gamma-lactones in moderate to good yields with high regio- and diastereoselectivities in ionic liquids. The employment of ionic liquids under mild reaction conditions makes this transformation green and practical. Especially, this reaction provided a novel and convenient methodology for the construction of naturally occurring biologically active beta- and gamma-lactones.

引用

页码：7219 / 7222

页数：4

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