Overhydration and low serum prealbumin predict peritoneal dialysis-related peritonitis in continuous ambulatory peritoneal dialysis patients

BackgroundIn this study, we focused on the role of overhydration (OH) and low serum prealbumin concentration in predicting peritonitis in continuous ambulatory peritoneal dialysis (CAPD) patients over a 3-year period.MethodsWe measured serum prealbumin concentration and OH by body composition monitor in 278 CAPD patients (159 males and 119 females) with a mean age of 46years and a median peritoneal dialysis (PD) duration of 21months. Cases of PD-related peritonitis were collected over 3years.ResultsAfter the 3-year follow-up, 44 patients were diagnosed with PD-related peritonitis (15.8%). Low education, serum glucose, prealbumin, and OH were independent risk factors for predicting peritonitis over 36months in CAPD patients. Based on the ROC curve model and Kaplan-Meier analysis, we realized that low prealbumin and high OH were independent predictors of 3-year peritonitis in CAPD patients (Prealbumin: AUC=0.838, cut-off value=32.5mg/dL, Se=90.9%, Sp=32.9%; OH: AUC=0.851, cut-off value=1.33L, Se=79.5%, Sp=85.5%; and log-rank test p< 0.001, respectively).ConclusionOverhydration and low serum prealbumin were the independent predictors of PD-related peritonitis in CAPD patients.