Association between migraine and ACE gene (insertion/deletion) polymorphism: the BioBIM study

被引：16
|
作者：
Palmirotta, Raffaele [1 ]
Barbanti, Piero [2 ]
Ludovici, Giorgia [1 ]
De Marchis, Maria Laura [1 ]
Ialongo, Cristiano [3 ]
Egeo, Gabriella [2 ]
Aurilia, Cinzia [2 ]
Fofi, Luisa [2 ]
Abete, Pasquale [4 ]
Spila, Antonella [1 ]
Ferroni, Patrizia [1 ]
Della-Morte, David [1 ,5 ]
Guadagni, Fiorella [1 ]
机构：
[1] IRCCS San Raffaele Pisana, Dept Adv Biotechnol & Bioimaging, Interinst Multidisciplinary BioBank BioBIM, Rome, Italy
[2] IRCCS San Raffaele Pisana, Dept Neurol Motor & Sensorial Sci, Headache & Pain Unit, I-00163 Rome, Italy
[3] Univ Roma Tor Vergata, Dept Internal Med, I-00133 Rome, Italy
[4] Univ Naples Federico II, Dept Translat Med Sci, I-80131 Naples, Italy
[5] Univ Roma Tor Vergata, Dept Syst Med, I-00133 Rome, Italy
来源：
PHARMACOGENOMICS | 2014年 / 15卷 / 02期
关键词：
ACE I/D polymorphism; genetics; migraine; pharmacological prophylaxis; ANGIOTENSIN-CONVERTING ENZYME; DELETION POLYMORPHISM; PROPHYLAXIS; DISEASE; I/D; EXPERIENCE; EFFICACY; INCREASE; SYSTEM; AURA;
D O I：
10.2217/pgs.13.186
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim:In the present case-control study, we investigated the correlation between the common ACE insertion/deletion (I/D) polymorphism and migraine. Materials & methods: Genotyping of the ACE I/D variant was performed in 502 Caucasian patients with migraine and 323 age-, sex- and race/ethnicity-matched healthy controls. We investigated associations between ACE genetic variants and sociodemographic and/or clinical features of migraineurs. Results: We found a significant association between ACE insertion/insertion (I/I) polymorphism and lower use of pharmacological prophylaxis in migraine patients with aura and in those with chronic migraine. Moreover, ACE I/I polymorphism was significantly more common in migraine patients with aura who had a negative family history of migraine. Conclusion: Our data suggest that although the ACE I/D polymorphism is not a direct risk factor for migraine, the ACE I/I genotype may influence the clinical feature of this disease being associated with reduced use of prophylactic agents in patients with migraine with aura and in those with chronic migraine.
引用
收藏
页码：147 / 155
页数：9
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