Anti-PD-1 monoclonal antibody Cancer immunotherapy

被引:0
作者
da Silva, R. Moreira
机构
关键词
Tumor immunity; Melanoma; Renal cell cancer; Non-small cell lung cancer; Nivolumab; BMS-936558; T-CELL-ACTIVATION; PROGRAMMED DEATH-1; PD-1; EXPRESSION; BLOCKADE; LIGANDS; ANTIGEN; SAFETY; B7-H1; AUTOIMMUNITY; REGRESSION;
D O I
10.1358/dof.2014.39.1.2103754
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Mechanistic studies to understand how immune checkpoint blockade induces regressions in several types of cancer have identified therapies that enhance tumor immunity as a treatment strategy. The programmed cell death protein 1 (hPD-1) receptor is a co-inhibitory receptor expressed by activated T lymphocytes. Anti-hPD-1 and anti-programmed cell death 1 ligand 1 (PD-L1) antibodies potentiate immune responses by blocking the interaction between the PD-1 protein and one of its ligands (PD-L), thereby preventing activated cells from becoming anergic, while preserving antitumor immunological activity. Nivolumab, a fully human IgG(4) antibody that blocks this receptor, has been demonstrated to produce durable objective responses, particularly in patients with melanoma, renal cell cancer and non-small cell lung cancer, while exhibiting a better safety profile compared with similar agents acting upon other checkpoint receptors. Herewith, we review all available evidence to illustrate nivolumab's immunological mechanism of action, its pharmacokinetic/pharmacodynamic and safety profile, and preclinical and clinical trials to date with nivolumab alone or combined with other immunomodulators/chemotherapeutics.
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页码:15 / 24
页数:10
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