Synthesis and Evaluation of Novel 5-cyclohexyl-2-(4"-substitutedphenyl)3-( 2"-substitutedphenyl) 4H-2,3,3a, 5,6,6a-hexahydropyrrolo[ 3,4-d] isoxazole-4,6-dione Derivatives for Their In Vitro Antioxidant and Antibacterial Activities

[GRAPHICS] 1,3-Dipolar cycloaddition reactions of N-cyclohexyl maleimide (1) with azomethine N-oxide (2) have afforded novel isoxazolidine (3) in excellent yield. Their structures have been characterized from their IR, H-1-NMR, C-13-NMR, H-1, H-1-COSY, MS(ESI), and elemental analysis techniques. In vitro antibacterial activity of the synthesized compounds were investigated against a representative panel of pathogenic strains specifically two Gram-positive bacteria (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative bacteria (Pseudomonas aeruginosa and Escherichia coli) using agar-well diffusion assay. Some of the compounds (3a, 3k, 3n, and 3o) exhibited promising antibacterial activities. All the synthesized compounds have also been screened for their antioxidant activities and were found to be significantly active.