Virion Assembly and Release

被引：87
作者：
Lindenbach, Brett D. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Microbial Pathogenesis, New Haven, CT 06536 USA
来源：
HEPATITIS C VIRUS: FROM MOLECULAR VIROLOGY TO ANTIVIRAL THERAPY | 2013年 / 369卷
关键词：
HEPATITIS-C-VIRUS; NONSTRUCTURAL PROTEIN 5A; LOW-DENSITY LIPOPROTEINS; VIRAL-RNA REPLICATION; HUMAN HEPATOMA-CELLS; NON-B HEPATITIS; CORE PROTEIN; APOLIPOPROTEIN-B; ENDOPLASMIC-RETICULUM; ENVELOPE GLYCOPROTEINS;
D O I：
10.1007/978-3-642-27340-7_8
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Hepatitis C Virus (HCV) particles exhibit several unusual properties that are not found in other enveloped RNA viruses, most notably their low buoyant density and interaction with serum lipoproteins. With the advent of systems to grow HCV in cell culture, the molecular basis of HCV particle assembly and release can now be addressed. The process of virus assembly involves protein-protein interactions between viral structural and nonstructural proteins and the coordinated action of host factors. This chapter reviews our current understanding of these interactions and factors.
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收藏
页码：199 / 218
页数：20
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