Synthesis of novel quinolinomatrine derivatives and their insecticidal/ acaricidal activities

被引：18
作者：
Huang, Jiulin [1 ,2 ]
Lv, Min [1 ]
Thapa, Sunita [1 ]
Xu, Hui [1 ,3 ]
机构：
[1] Northwest A&F Univ, Coll Sci Plant Protect, Res Inst Pesticidal Design & Synth, Yangling 712100, Shaanxi, Peoples R China
[2] Ankang Univ, Sch Chem & Chem Engn, Ankang 725000, Shaanxi, Peoples R China
[3] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2018年 / 28卷 / 10期
基金：
中国国家自然科学基金;
关键词：
Matrine; Quinoline; Insecticidal activity; Acaricidal activity; ANTIPLASMODIAL ACTIVITY; BIOLOGICAL EVALUATION; ESTER DERIVATIVES; AGENTS; MATRINE; PODOPHYLLOTOXIN; SEMISYNTHESIS; ANALOGS; DESIGN; SERIES;
D O I：
10.1016/j.bmcl.2018.04.029
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
In continuation of our program to discover natural product-based pesticidal agents, a series of new quinolinomatrine derivatives were prepared. Especially three-dimensional structures of five compounds were unambiguously determined by single-crystal X-ray diffraction. Among them, 21-chloroquinolinomatrine exhibited good insecticidal and acaricidal activities against two crop-threatening insect pests, Mythimna separata and Tetranychus annabaricins. Their structure-activity relationships were also discussed. (C) 2018 E(C)sevier Ltd. All rights reserved.
引用
收藏
页码：1753 / 1757
页数：5
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