Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer

被引：8

作者：

Zhang, Xiao ^{[1
]}

Wang, Yulan ^{[1
]}

Wang, Jiayi ^{[1
,2
]}

Sun, Fenyong ^{[1
]}

机构：

[1] Tongji Univ, Shanghai Peoples Hosp 10, Dept Clin Lab Med, Shanghai 200072, Peoples R China

[2] Tongji Univ, Translat Med High Inst, Shanghai 200092, Peoples R China

来源：

ONCOLOGY REPORTS | 2016年 / 35卷 / 02期

关键词：

signal transduction; PI3K/AKT signaling; therapy; apoptosis; hepatocellular carcinoma; PPI investigation; HUMAN HEPATOCELLULAR-CARCINOMA; RAPAMYCIN COMPLEX 1; KAPPA-B ACTIVATION; MAMMALIAN TARGET; IN-VIVO; MEDIATED PHOSPHORYLATION; TRANSCRIPTIONAL ACTIVITY; DEPENDENT REGULATION; NEGATIVE REGULATION; INDUCED APOPTOSIS;

D O I：

10.3892/or.2015.4464

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Numerous signaling pathways have been shown to be dysregulated in liver cancer. In addition, some protein-protein interactions are prerequisite for the uncontrolled activation or inhibition of these signaling pathways. For instance, in the PI3K/AKT signaling pathway, protein AKT binds with a number of proteins such as mTOR, FOXO1 and MDM2 to play an oncogenic role in liver cancer. The aim of the present review was to focus on a series of important protein-protein interactions that can serve as potential therapeutic targets in liver cancer among certain important pro-carcinogenic signaling pathways. The strategies of how to investigate and analyze the protein-protein interactions are also included in this review. A survey of these protein interactions may provide alternative therapeutic targets in liver cancer.

引用

页码：625 / 638

页数：14

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