The USA Multicenter Prehosptial Hemoglobin-based Oxygen Carrier Resuscitation Trial: Scientific Rationale, Study Design, and Results

被引：22

作者：

Moore, Ernest E. ^{[1
]}

Johnson, Jeffrey L. ^{[1
]}

Moore, Frederick A. ^{[3
,4
]}

Moore, Hunter B. ^{[2
]}

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Surg, Denver Hlth Med Ctr, Denver, CO 80204 USA

[2] Univ Vermont, Sch Med, Burlington, VT 05405 USA

[3] Methodist Hosp, Dept Surg, Houston, TX 77030 USA

[4] Weill Cornell Univ, Houston, TX USA

来源：

CRITICAL CARE CLINICS | 2009年 / 25卷 / 02期

关键词：

Hemoglobin-based oxygen carrier; Blood substitute; Prehospital resuscitation; Hemorrhagic shock; Trauma; HUMAN POLYMERIZED HEMOGLOBIN; CROSS-LINKED HEMOGLOBIN; INDEPENDENT RISK-FACTOR; ACUTE LUNG INJURY; HEMORRHAGIC-SHOCK; BLOOD SUBSTITUTE; PYRIDOXYLATED HEMOGLOBIN; HYPOTENSIVE RESUSCITATION; PULMONARY-HYPERTENSION; LUMBRICUS-TERRESTRIS;

D O I：

10.1016/j.ccc.2009.01.002

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Human polymerized hemoglobin (PolyHeme) is a universally compatible oxygen carrier developed for use when red blood cells are unavailable and oxygen-carrying replacement is needed to treat life-threatening anemia. This multicenter phase III trial assessed survival of patients resuscitated with a hemoglobin-based oxygen carrier starting at the scene of injury. Patients resuscitated with PolyHeme had outcomes comparable to those receiving the standard of care including rapid access to stored red blood cells. Although there were more adverse events in the PolyHeme group compared with control patients receiving blood, the observed safety profile is acceptable for the intended population. The benefit-to-risk ratio of PolyHeme is favorable when blood is needed but is not available or an option.

引用

页码：325 / +

页数：33

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