Stereoselective synthesis of enantiomerically pure 4,5-disubstituted pyrrolidinones from β-amino esters

被引：25

作者：

Wang, JB ^{[1
]}

Hou, YH

Wu, P

Qu, ZH

Chan, ASC

机构：

[1] Beijing Univ, Dept Chem, Beijing 100871, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 23期

基金：

中国国家自然科学基金;

关键词：

D O I：

10.1016/S0957-4166(99)00530-3

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

alpha-Alkylation of N-tosyl-protected beta-amino esters with LDA as the base led to high anti selectivity for the newly formed C-C bond. The alpha-alkylated beta-amino esters were further transformed to enantiomerically pure 4,5-disubstituted pyrrolidinones through hydrolysis, diazotization, and Wolf rearrangement under AgO2CPh/Et3N/dry THF conditions. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：4553 / 4561

页数：9

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