A shortened, protecting group free, synthesis of the anti-wrinkle venom analogue Syn-Ake® exploiting an optimized Hofmann-type rearrangement

被引：11

作者：

Balaev, A. N. ^{[1
]}

Okhmanovich, K. A. ^{[1
]}

Osipov, V. N. ^{[1
]}

机构：

[1] Pharm Sintez, Moscow 115419, Russia

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 42期

关键词：

Peptides; Tripeptide; Syn-Ake (R); Hofmann-type rearrangement; mnAChR antagonist;

D O I：

10.1016/j.tetlet.2014.08.117

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An unusual five-step synthesis of H-beta-Ala-Pro-DabNHBz diacetate (a muscular nicotinic acetylcholine receptor antagonist) has been delineated through Hofmann-type rearrangement as a final step to build the target skeleton. The synthesis has been carried out using a protecting group free strategy and employed readily available reagents as the starting materials. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5745 / 5747

页数：3

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