FOXO1, TGF-β Regulation and Wound Healing

被引：90

作者：

Hameedaldeen, Alhassan ^{[1
]}

Liu, Jian ^{[2
]}

Batres, Angelika ^{[1
]}

Graves, Gabrielle S. ^{[3
]}

Graves, Dana T. ^{[1
]}

机构：

[1] Univ Penn, Sch Dent Med, Philadelphia, PA 19104 USA

[2] Hebei Med Univ, Dept Stomatol, Hosp 4, Shijiazhuang 050011, Peoples R China

[3] Med Coll Wisconsin, Dept Med, Milwaukee, WI 53226 USA

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 09期

关键词：

cell death; epithelial; FOXO; transforming growth factor-beta; migration; proliferation; repair; ROS; skin; wound; PROLIFERATOR-ACTIVATED RECEPTOR; OXIDATIVE STRESS; TRANSCRIPTION FACTOR; GROWTH-FACTORS; MICE LACKING; STEM-CELLS; IN-VITRO; APOPTOSIS; REPAIR; SKIN;

D O I：

10.3390/ijms150916257

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Re-epithelialization is a complex process that involves migration and proliferation of keratinocytes, in addition to the production of cytokines and growth factors that affect other cells. The induction of transcription factors during these processes is crucial for successful wound healing. The transcription factor forkhead boxO-1 (FOXO1) has recently been found to be an important regulator of wound healing. In particular, FOXO1 has significant effects through regulation of transforming growth factor-beta (TGF-beta) expression and protecting keratinocytes from oxidative stress. In the absence of FOXO1, there is increased oxidative damage, reduced TGF-beta 1 expression, reduced migration and proliferation of keratinocytes and increased keratinocytes apoptosis leading to impaired re-epithelialization of wounds.

引用

页码：16257 / 16269

页数：13

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