Peripheral Neuropathy in Beta-Thalassemia: Corneal Confocal Microscopy-Based Study

被引:0
作者
Khan, Saad A. [1 ]
Naqvi, Syed Ali H. [1 ]
Saeed, Amber [1 ]
Khan, Wajid A. [1 ]
Moqeet, Muhammad A. [1 ]
Ali, Warda [1 ]
Khan, Faheem U. [1 ]
机构
[1] Al Shifa Trust Eye Hosp, Cornea & Refract Surg, Rawalpindi, Pakistan
关键词
nerve density; corneal nerves; confocal microscopy; peripheral neuropathy; beta-thalassemia; NERVE DENSITY; DISEASE;
D O I
10.7759/cureus.32122
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
BackgroundPeripheral neuropathy is a controversial but serious complication of beta-thalassemia (I3-Th). Although few studies have reported no relationship between neuropathy and thalassemia, many have linked it with increasing age, iron overload, and iron chelator toxicity. This study aims to investigate the presence of neuropathy in I3-Th using corneal nerve fibers.MethodologyA cross-sectional study was conducted using corneal confocal microscopy on individuals with intermediate and major I3-Th who were compared to healthy individuals. The main outcome variables were corneal main nerve and branch nerve densities which were calculated using Image J software. The comparison between groups was done using the independent-samples F-test and Bonferroni post-hoc analysis.ResultsThere was reduced corneal main nerve and branch nerve density in I3-Th intermediate and major patients compared to the control group, and the results were statistically significant (p-value <0.05). However, a significant correlation was not observed between serum ferritin levels and corneal nerve parameters.ConclusionsThe reduction in corneal nerve parameters in I3-Th patients compared to healthy controls can be an indication of peripheral neuropathy in I3-Th. Further work is needed to confirm these findings.
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页数:7
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