As one of major environmental endocrine disruptors (EEDs), bisphenol A (BPA) has been drawn increasingly lots of people in the world, which is also widely identified as an indispensable raw chemical in plastics production, food cans and dental composites. With increasing demand and production capacity of BPA, more BPA will enter into and contaminate the environment. So it has become a challenge that excess BPA jeopardizes the health of human being. Considering a pretty low dose of BPA existing in the environment, some advanced analysis techniques have been carried out to analysis BPA, such as HLPC, GC-MS, LC-MS. Compared with other physical and chemical treatment technology, biological treatment technology has the advantage of low cost and high efficiency.