Decarbonylative Coupling of α-Keto Acids and Ynamides for Synthesis of β-Keto Imides

被引：35

作者：

Chen, Renjie ^{[1
]}

Zeng, Linwei ^{[1
]}

Huang, Bo ^{[1
]}

Shen, Yangyong ^{[1
]}

Cui, Sunliang ^{[1
,2
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Drug Discovery & Design, Hangzhou 310058, Zhejiang, Peoples R China

[2] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China

来源：

ORGANIC LETTERS | 2018年 / 20卷 / 11期

基金：

中国国家自然科学基金;

关键词：

YNE-TETHERED YNAMIDE; ASYMMETRIC BIOMIMETIC TRANSAMINATION; DECARBOXYLATIVE ACYLATION; REGIOSELECTIVE SYNTHESIS; OXOCARBOXYLIC ACIDS; C-H; CYCLIZATION; ACCESS; ESTERS; CYCLOADDITION;

D O I：

10.1021/acs.orglett.8b01302

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel decarbonylative coupling of alpha-keto acids and ynamides with extrusion of CO for synthesis of beta-keto imides is reported. This process features mild reaction conditions, a broad substrate scope, and high efficiency. An isotope-labeling reaction and GC analysis were conducted to elucidate a plausible reaction mechanism.

引用

页码：3377 / 3380

页数：4

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