Synthesis and Characterization of Glycoconjugated Porphyrin Triphenylamine Hybrids for Targeted Two-Photon Photodynamic Therapy

被引：61
|
作者：
Hammerer, Fabien [1 ,2 ,3 ,4 ]
Garcia, Guillaume [1 ,2 ,3 ,4 ]
Chen, Su [1 ,2 ,3 ,4 ]
Poyer, Florent [1 ,3 ,4 ,5 ]
Achelle, Sylvain [1 ,2 ,3 ,4 ]
Fiorini-Debuisschert, Celine [6 ]
Teuade-Fichou, Marie-Paule [1 ,2 ,3 ,4 ]
Maillard, Philippe [1 ,2 ,3 ,4 ]
机构：
[1] Ctr Univ, Inst Curie, Sect Rech, F-91405 Orsay, France
[2] Ctr Univ, CNRS, UMR 176, F-91405 Orsay, France
[3] Univ Paris Sud, Ctr Univ, F-91405 Orsay, France
[4] Univ Toulouse 3, PHOTOMED, CNRS GDR 3049, UMR 5623, F-31062 Toulouse 9, France
[5] Ctr Univ, INSERM, U759, F-91405 Orsay, France
[6] CEA Saclay, DSM IRAMIS, SPCSI Lab Nanophoton, F-91191 Gif Sur Yvette, France
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 03期
关键词：
HUMAN RETINOBLASTOMA; OPTICAL-PROPERTIES; SINGLET OXYGEN; ONE-PHOTON; ABSORPTION; PHOTOSENSITIZERS; RESONANCE; TUMOR; ENHANCEMENT; STRATEGIES;
D O I：
10.1021/jo402658h
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
In order to avoid side effects at the time of cancer eradication to the patients, the selectivity of treatments. has become of strategic importance. In the case of photo-dynamic therapy (PDT), two-photon absorption combined with active targeting of tumors could allow both spatial and chemical selectivity. In this context, we present the synthesis, spectroscopic, and biological properties of a series of porphyrin-triphenylamine hybrids with excellent singlet oxygen production capacities and good two-photon absorption.
引用
收藏
页码：1406 / 1417
页数：12
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