Synthesis and Characterization of Glycoconjugated Porphyrin Triphenylamine Hybrids for Targeted Two-Photon Photodynamic Therapy

被引：61

作者：

Hammerer, Fabien ^{[1
,2
,3
,4
]}

Garcia, Guillaume ^{[1
,2
,3
,4
]}

Chen, Su ^{[1
,2
,3
,4
]}

Poyer, Florent ^{[1
,3
,4
,5
]}

Achelle, Sylvain ^{[1
,2
,3
,4
]}

Fiorini-Debuisschert, Celine ^{[6
]}

Teuade-Fichou, Marie-Paule ^{[1
,2
,3
,4
]}

Maillard, Philippe ^{[1
,2
,3
,4
]}

机构：

[1] Ctr Univ, Inst Curie, Sect Rech, F-91405 Orsay, France

[2] Ctr Univ, CNRS, UMR 176, F-91405 Orsay, France

[3] Univ Paris Sud, Ctr Univ, F-91405 Orsay, France

[4] Univ Toulouse 3, PHOTOMED, CNRS GDR 3049, UMR 5623, F-31062 Toulouse 9, France

[5] Ctr Univ, INSERM, U759, F-91405 Orsay, France

[6] CEA Saclay, DSM IRAMIS, SPCSI Lab Nanophoton, F-91191 Gif Sur Yvette, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 03期

关键词：

HUMAN RETINOBLASTOMA; OPTICAL-PROPERTIES; SINGLET OXYGEN; ONE-PHOTON; ABSORPTION; PHOTOSENSITIZERS; RESONANCE; TUMOR; ENHANCEMENT; STRATEGIES;

D O I：

10.1021/jo402658h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In order to avoid side effects at the time of cancer eradication to the patients, the selectivity of treatments. has become of strategic importance. In the case of photo-dynamic therapy (PDT), two-photon absorption combined with active targeting of tumors could allow both spatial and chemical selectivity. In this context, we present the synthesis, spectroscopic, and biological properties of a series of porphyrin-triphenylamine hybrids with excellent singlet oxygen production capacities and good two-photon absorption.

引用

页码：1406 / 1417

页数：12

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