Non-ionic macroporous polystyrene adsorbents for removal of serum toxins in liver failure by hemoperfusion

被引：47

作者：

Chen, Jian ^{[1
]}

Han, Wenyan ^{[1
]}

Su, Rui ^{[2
]}

Chen, Jie ^{[1
]}

Zong, Wenhui ^{[1
]}

Wang, Yue ^{[1
]}

Wang, Weichao ^{[1
]}

Cheng, Guanghui ^{[1
]}

Ou, Lailiang ^{[1
]}

Yu, Yaoting ^{[1
]}

机构：

[1] Nankai Univ, Coll Life Sci, Key Lab Bioact Mat, Minist Educ, Tianjin, Peoples R China

[2] Second Peoples Hosp, Inst Hepatopathy Med Res, Tianjin, Peoples R China

来源：

ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2017年 / 45卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Blood purification; liver failure; non-ionic adsorbents; polystyrenel serum toxins; STYRENE-DIVINYLBENZENE COPOLYMERS; BILIRUBIN REMOVAL; BLOOD PURIFICATION; ACTIVATED CARBON; HEPATIC-FAILURE; EXCHANGE RESIN; ADSORPTION; ALBUMIN; HYPERBILIRUBINEMIA; ISOTHERMS;

D O I：

10.3109/21691401.2016.1138494

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Strong base anion exchange resin (e.g., BL-300) is currently used to eliminate bilirubin from blood in clinical hemoperfusion. However, there is a potential weakness of the resin to remove heparin and activation of coagulation. To overcome this weakness, we prepared a novel non-ionic macroporous polystyrene adsorbent (SZ-9) with rich mesopores and high surface area by suspension polymerization. Test results indicated that SZ-9 performed better adsorption capacity for bilirubin than BL-300. In addition, better blood compatibility was observed during whole blood hemoperfusion. Therefore, adsorbent SZ-9 might be an efficient alternative to anion exchange resin for the removal of bilirubin in hemoperfusion.

引用

页码：174 / 183

页数：10

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