Management Strategies for Heart Failure with Preserved Ejection Fraction

被引：11

作者：

Vazir, Ali ^{[1
,2
,3
]}

Solomon, Scott D. ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med, Div Cardiovasc, Boston, MA 02115 USA

[2] Univ London Imperial Coll Sci Technol & Med, Royal Brompton Hosp, Royal Brompton & Harefield NHS Fdn Trust, NIHR Cardiovasc Biomed Res Unit, London, England

[3] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Inst Cardiovasc Med & Sci, London, England

来源：

HEART FAILURE CLINICS | 2014年 / 10卷 / 04期

关键词：

Heart failure; Preserved ejection fraction; LCZ696; DIASTOLIC FUNCTION; EXERCISE CAPACITY; CARDIAC FIBROSIS; TASK-FORCE; SPIRONOLACTONE; DYSFUNCTION; MORTALITY; INTERVENTION; HYPERTENSION; POPULATION;

D O I：

10.1016/j.hfc.2014.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The management of heart failure with preserved ejection fraction (HFpEF) is challenging and requires an accurate diagnosis. Although currently there is no convincing therapy that prolongs survival in patients with HFpEF, treatment of fluid retention and of comorbidities, such as hypertension, myocardial ischemia, and atrial fibrillation, may improve symptoms and quality of life. Future outcome trials testing the efficacy of promising new agents will have better characterization of patient phenotype to maximize the potential response to therapies. This article provides current management strategies available for HFpEF, gives an overview of previous trials that have failed to prove the benefit of therapies to improve outcomes, and highlights promising novel therapies.

引用

页码：591 / +

页数：9

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