Antibacterial activity study of 1,2,4-triazole derivatives

被引：220
|
作者：
Gao, Feng [1 ,2 ,3 ]
Wang, Tengfei [1 ]
Xiao, Jiaqi [1 ,3 ]
Huang, Gang [3 ]
机构：
[1] Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking LB, Jinan, Shandong, Peoples R China
[2] Nanjing Univ, Med Sch, Jinling Hosp, Dept Med Imaging, Nanjing, Jiangsu, Peoples R China
[3] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2019年 / 173卷
基金：
中国国家自然科学基金;
关键词：
1,2,4-triazole; Hybrid compounds; Antibacterial activity; Structure-activity relationship; MICROWAVE-ASSISTED SYNTHESIS; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; IN-VITRO; QUINOLONE DERIVATIVES; BIOACTIVE EVALUATION; EFFICIENT SYNTHESIS; TRIAZOLE HYBRIDS; ISATIN HYBRIDS; DESIGN;
D O I：
10.1016/j.ejmech.2019.04.043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antibiotics are commonly used to fight against bacterial infections, but bacteria have already been resistant to almost all antibiotics due to abuse of antibiotics. 1,2,4-Triazole derived compounds possess chemotherapeutic effects including potential antibacterial activities against drug-sensitive as well as drug-resistant pathogens. Hybridization displays a high potential to develop novel drugs with the capacity to overcome drug resistance, reduce toxicity and improve pharmacokinetic profiles. More effective antibacterial candidates might be obtained by the hybridization of 1,2,4-triazole with other antibacterial pharmacophores. This review summarizes the recent advances of 1,2,4-triazole derivatives as potential antibacterial compounds, and the structure-activity relationship is also discussed. (C) 2019 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：274 / 281
页数：8
相关论文
共 50 条
  • [1] eSynthesis, antibacterial and surface activity of 1,2,4-triazole derivatives
    El-Sayed, R.
    GRASAS Y ACEITES, 2006, 57 (02) : 180 - 188
  • [2] Synthesis, antibacterial and surface activity of 1,2,4-triazole derivatives
    El-Sayed, R
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 2006, 45 (03): : 738 - 746
  • [3] Synthesis, antifungal and antibacterial activity of novel 1,2,4-triazole derivatives
    Gupta, Deepa
    Jain, D. K.
    JOURNAL OF ADVANCED PHARMACEUTICAL TECHNOLOGY & RESEARCH, 2015, 6 (03) : 141 - 146
  • [4] Preparation and Evaluation of Antibacterial Activity of Some New 1,2,4-Triazole Derivatives
    Arafa, W. A. A.
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2010, 47 (05) : 1109 - 1115
  • [5] SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF SOME NEW DERIVATIVES OF THIOSEMICARBAZIDE AND 1,2,4-TRIAZOLE
    Wujec, Monika
    Pachuta-Stec, Anna
    Stefanska, Joanna
    Kusmierz, Edyta
    Siwek, Agata
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2013, 188 (11) : 1661 - 1669
  • [6] Synthesis of Novel Tris-1,2,4-triazole Derivatives and Their Antibacterial Activity
    S. Shiroud Ghorbani
    N. Montazeri
    M. M. Zeydi
    M. Ghane
    Russian Journal of Organic Chemistry, 2021, 57 : 605 - 610
  • [7] Synthesis of Novel Tris-1,2,4-triazole Derivatives and Their Antibacterial Activity
    Ghorbani, S. Shiroud
    Montazeri, N.
    Zeydi, M. M.
    Ghane, M.
    RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2021, 57 (04) : 605 - 610
  • [8] Antiviral activity of 1,2,4-triazole derivatives (microreview)
    Simurova, Nataliia, V
    Maiboroda, Olena, I
    CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2021, 57 (04) : 420 - 422
  • [9] Synthesis and insecticidal activity of 1,2,4-triazole derivatives
    Chai, B
    Qian, XH
    Cao, S
    Liu, HD
    Song, GH
    ARKIVOC, 2003, : 141 - 145
  • [10] 1,2,4-triazole derivatives with morpholine; DFT study and antileishmanial activity
    Suleymanoglu, Nevin
    Ustabas, Resat
    Direkel, Sahin
    Alpaslan, Yelda Bingol
    Unver, Yasemin
    CANADIAN JOURNAL OF PHYSICS, 2018, 96 (07) : 719 - 723
12345