Crystal Structure of Marburg Virus VP24

被引：15

作者：

Zhang, Adrianna P. P. ^{[1
]}

Bornholdt, Zachary A. ^{[1
]}

Abelson, Dafna M. ^{[1
]}

Saphire, Erica Ollmann ^{[1
,2
]}

机构：

[1] Scripps Res Inst, Dept Immunol & Microbial Sci, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 10期

关键词：

PROTEIN; REPLICATION; KARYOPHERIN;

D O I：

10.1128/JVI.03565-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The VP24 protein plays an essential, albeit poorly understood role in the filovirus life cycle. VP24 is only 30% identical between Marburg virus and the ebolaviruses. Furthermore, VP24 from the ebolaviruses is immunosuppressive, while that of Marburg virus is not. The crystal structure of Marburg virus VP24, presented here, reveals that although the core is similar between the viral genera, Marburg VP24 is distinguished by a projecting beta-shelf and an alternate conformation of the N-terminal polypeptide.

引用

页码：5859 / 5863

页数：5

共 50 条

[1] VP24 of Marburg virus influences formation of infectious particles
Bamberg, S
Kolesnikova, L
Möller, P
Klenk, HD
Becker, S
JOURNAL OF VIROLOGY, 2005, 79 (21) : 13421 - 13433
[2] Molecular Basis of the Marburg Virus Protein VP24 Interactions with Human Keap1
Bhattarai, Nisha
Chapagain, Prem P.
Gerstman, Bernard
BIOPHYSICAL JOURNAL, 2019, 116 (03) : 182A - 182A
[3] Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus
Lifang Sun
Yintao Su
Yanhe Zhao
Zheng-qing Fu
Yunkun Wu
Scientific Reports, 6
[4] Crystal Structure of Major Envelope Protein VP24 from White Spot Syndrome Virus
Sun, Lifang
Su, Yintao
Zhao, Yanhe
Fu, Zheng-qing
Wu, Yunkun
SCIENTIFIC REPORTS, 2016, 6
[5] The Marburg Virus VP24 Protein Interacts with Keap1 to Activate the Cytoprotective Antioxidant Response Pathway
Edwards, Megan R.
Johnson, Britney
Mire, Chad E.
Xu, Wei
Shabman, Reed S.
Speller, Lauren N.
Leung, Daisy W.
Geisbert, Thomas W.
Amarasinghe, Gaya K.
Basler, Christopher F.
CELL REPORTS, 2014, 6 (06): : 1017 - 1025
[6] Regulation of the Ebola Virus VP24 Protein by SUMO
Vidal, Santiago
El Motiam, Ahmed
Seoane, Rocio
Preitakaite, Viktorija
Hichem Bouzaher, Yanis
Gomez-Medina, Sergio
San Martin, Carmen
Rodriguez, Dolores
Teresa Rejas, Maria
Baz-Martinez, Maite
Barrio, Rosa
Sutherland, James D.
Rodriguez, Manuel S.
Munoz-Fontela, Cesar
Rivas, Carmen
JOURNAL OF VIROLOGY, 2020, 94 (01)
[7] Crystal Structure of the Marburg Virus VP35 Oligomerization Domain
Bruhn, Jessica F.
Kirchdoerfer, Robert N.
Urata, Sarah M.
Li, Sheng
Tickle, Ian J.
Bricogne, Gerard
Saphire, Erica Ollmann
JOURNAL OF VIROLOGY, 2017, 91 (02)
[8] Role of Ebola Virus vp24 Protein in Inhibition of Interferonogenesis
Shelemba, A. A.
Lushnikova, E. L.
Kolesnikov, S. I.
Nepomnyashchikh, L. M.
Chepurnov, A. A.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE, 2016, 160 (03) : 350 - 352
[9] Regions in Ebola virus VP24 that are important for nucleocapsid formation
Noda, Takeshi
Halfmann, Peter
Sagara, Hiroshi
Kawaoka, Yoshihiro
JOURNAL OF INFECTIOUS DISEASES, 2007, 196 : S247 - S250
[10] Role of Ebola Virus vp24 Protein in Inhibition of Interferonogenesis
A. A. Shelemba
E. L. Lushnikova
S. I. Kolesnikov
L. M. Nepomnyashchikh
A. A. Chepurnov
Bulletin of Experimental Biology and Medicine, 2016, 160 : 350 - 352

← 1 2 3 4 5 →