Concise and regioselective synthesis of 5H-imidazo[1,2-e][1,3,5]triazepines

被引：2

作者：

Demydchuk, Bohdan A. ^{[1
]}

Mykhalchenko, Oleksandr A. ^{[2
]}

Rusanov, Eduard B. ^{[3
]}

Moskvina, Viktoriia S. ^{[1
]}

Brovarets, Volodymyr S. ^{[1
]}

机构：

[1] VP Kukhar Inst Bioorgan Chem & Petrochem NAS Ukra, Murmanska Str 1, UA-02094 Kiev, Ukraine

[2] Natl Tech Univ Ukraine, Igor Sikorsky Kyiv Polytech Inst, Peremohy Ave 37, UA-03056 Kiev, Ukraine

[3] Natl Acad Sci Ukraine, Inst Organ Chem, Murmanska Str 5, UA-02660 Kiev, Ukraine

来源：

ARKIVOC | 2022年

关键词：

Tetrachloro-2-aza-1; 3-butadienes; (1H-imidazol-2-yl)methanamine; 1; 3; 5-triazepine; imidazotriazepine; regioselective annulation; ANALOGS EXHIBIT POTENT; EFFICIENT SYNTHESIS; NUCLEOSIDE; INHIBITION; VIRUS;

D O I：

10.24820/ark.5550190.p011.689

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this communication, we report a regioselective synthesis of novel 5H-imidazo[1,2-e][1,3,5]triazepines via the interaction of tetrachloro-2-aza-1,3-butadienes with (1H-imidazol-2-yl)methanamine. The advantages of the presented method are mild reaction conditions, a simple work-up procedure, available reagents, and high yields. A possible mechanism is proposed for the synthesis of key products. The structure of one of the obtained products was proven with asingle crystal X-ray diffraction-based structure.

引用

页码：204 / 214

页数：11

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