AngiomiRs-Key regulators of angiogenesis

被引：397

作者：

Wang, Shusheng ^{[1
]}

Olson, Eric N. ^{[1
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Mol Biol, Dallas, TX 75390 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2009年 / 19卷 / 03期

基金：

美国国家卫生研究院;

关键词：

MICROVASCULAR ENDOTHELIAL-CELLS; EMBRYONIC STEM-CELLS; MICRORNA EXPRESSION; VASCULAR INTEGRITY; BREAST-CANCER; GROWTH; HYPOXIA; DICER; EGFL7; MIR-126;

D O I：

10.1016/j.gde.2009.04.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The formation of new blood vessels through the process of angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to a variety of diseases, such as ischemia and cancer. Recent studies have revealed important roles for miRNAs in regulating endothelial cell (EC) function, especially angiogenesis. Mice with EC-specific deletion of Dicer, a key enzyme for generating miRNAs, display defective postnatal angiogenesis. Specific miRNAs (angiomiRs) have recently been shown to regulate angiogenesis in vivo. miRNA-126, an EC-restricted miRNA, regulates vascular integrity and developmental angiogenesis. miR-378, miR-296, and the miR-17-92 cluster contribute to tumor angiogenesis. Manipulating angiomiRs in the settings of pathological vascularization represents a new therapeutic approach.

引用

页码：205 / 211

页数：7

共 53 条

[1] MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer [J].

Asangani, I. A. ;

Rasheed, S. A. K. ;

Nikolova, D. A. ;

Leupold, J. H. ;

Colburn, N. H. ;

Post, S. ;

Allgayer, H. .

ONCOGENE, 2008, 27 (15) :2128-2136

[2] Procoagulant membrane microparticles correlate with the severity of pulmonary arterial hypertension [J].

Bakouboula, Babe ;

Morel, Olivier ;

Faure, Antoine ;

Zobairi, Fatiha ;

Jesel, Laurence ;

Trinh, Annie ;

Zupan, Michel ;

Canuet, Matthieu ;

Grunebaum, Lelia ;

Brunette, Agnes ;

Desprez, Dominique ;

Chabot, Francois ;

Weitzenblum, Emmanuel ;

Freyssinet, Jean-Marie ;

Chaouat, Ari ;

Toti, Florence .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2008, 177 (05) :536-543

[3] Mammalian mirtron genes [J].

Berezikov, Eugene ;

Chung, Wei-Jen ;

Willis, Jason ;

Cuppen, Edwin ;

Lai, Eric C. .

MOLECULAR CELL, 2007, 28 (02) :328-336

[4] Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis [J].

Bruchova, Hana ;

Yoon, Donghoon ;

Agarwal, Archana M. ;

Mendell, Joshua ;

Prchal, Josef T. .

EXPERIMENTAL HEMATOLOGY, 2007, 35 (11) :1657-1667

[5] EGFL7 is a chemoattractant for endothelial cells and is up-regulated in angiogenesis and arterial injury [J].

Campagnolo, L ;

Leahy, A ;

Chitnis, S ;

Koschnick, S ;

Fitch, MJ ;

Fallon, JT ;

Loskutoff, D ;

Taubman, MB ;

Stuhlmann, H .

AMERICAN JOURNAL OF PATHOLOGY, 2005, 167 (01) :275-284

[6] hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer [J].

Camps, Carme ;

Buffa, Francesca M. ;

Colella, Stefano ;

Moore, John ;

Sotiriou, Christos ;

Sheldon, Helen ;

Harris, Adrian L. ;

Gleadle, Jonathan M. ;

Ragoussis, Jiannis .

CLINICAL CANCER RESEARCH, 2008, 14 (05) :1340-1348

[7] Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 [J].

Chen, Yun ;

Gorski, David H. .

BLOOD, 2008, 111 (03) :1217-1226

[8] MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines [J].

Crawford, M. ;

Brawner, E. ;

Batte, K. ;

Yu, L. ;

Hunter, M. G. ;

Otterson, G. A. ;

Nuovo, G. ;

Marsh, C. B. ;

Nana-Sinkam, S. P. .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 373 (04) :607-612

[9] FGF and VEGF function in angiogenesis: signalling pathways, biological responses and therapeutic inhibition [J].

Cross, MJ ;

Claesson-Welsh, L .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2001, 22 (04) :201-207

[10] Induction of MicroRNA-221 by Platelet-derived Growth Factor Signaling Is Critical for Modulation of Vascular Smooth Muscle Phenotype [J].

Davis, Brandi N. ;

Hilyard, Aaron C. ;

Nguyen, Peter H. ;

Lagna, Giorgio ;

Hata, Akiko .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 284 (06) :3728-3738

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