Cancer stem cells - from initiation to elimination, how far have we reached? (Review)

被引：17

作者：

Akhtar, Kamal ^{[1
]}

Bussen, Wendy ^{[1
]}

Scott, Shaun P. ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Radiat Oncol, St Louis, MO 63108 USA

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2009年 / 34卷 / 06期

关键词：

cancer stem cells; solid tumors; tumor initiation and progression; metastasis; cancer stem cell marker; tumor therapy; leukemia; self-renewal; ACUTE LYMPHOBLASTIC-LEUKEMIA; HEDGEHOG SIGNALING PATHWAY; MAMMARY EPITHELIAL-CELLS; ACUTE MYELOID-LEUKEMIA; TRUNCATED INT3 GENE; SELF-RENEWAL; PROGENITOR CELLS; SPORADIC MEDULLOBLASTOMAS; SIDE-POPULATION; SONIC HEDGEHOG;

D O I：

10.3892/ijo_00000278

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cancer stem cells (CSCs) are rare tumor cells that have the potential to proliferate, self-renew and induce tumorigenesis. Over the past few years, CSCs have been isolated from several different tumors and when implanted into immune-deficient mice, generate tumors that are identical to the parental tumors. In this review, we summarize the current literature on CSCs, which suggests that since these cells have the ability to drive tumor formation, specifically targeting them may lead to more effective therapies against tumors.

引用

页码：1491 / 1503

页数：13

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